临床神经病学杂志2024，Vol.37Issue(4)：278-282,5.
帕金森病前驱期轻度认知障碍患者认知域损害特征及危险因素分析
Analysis ofcharacteristics of cognitive domain damage and risk factors of prodromal Parkinson's disease patients with mild cognitive impairment
摘要
Abstract
Objective To investigate characteristics of cognitive domain damage and risk factors of prodromal Parkinson's disease(pPD)patients with mild cognitive impairment(MCI).Methods A total of 82 pPD patients and 41 normal controls(normal control group)were included.According to MCI,pPD patients were divided into pPD-MCI group and pPD control group(pPD-NC group).The difference of unified Parkinson's disease rating scale Ⅲ(UPDRS Ⅲ),30 items non-motor symptom questionnaire(NMSQ),Hamilton depression scale(HAMD-24),Hamilton anxiety scale(HAMA),MMSE,Montreal cognitive assessment scale(MoCA),Chinese university of Hong Kong rapid eye movement sleep behavior disorder scale(RBDQ-HK),German Burghart sniff stick test and z-scores of each cognitive domain were compared among the groups.Logistic regression analysis was used to analyze the influencing factors of MCI.Results Compared with those in pPD-NC group,UPDRS Ⅲ score in pPD-MCI group was significantly increased,and MoCA score in pPD-MCI group was significantly decreased(P<0.05-0.01).There was no significant difference in NMSQ,HAMA,HAMD-24,MMSE,German Burghart sniff stick test and RBDQ-HK score between pPD-MCI group and pPD-NC group(all P>0.05).Compared with those in pPD-NC group,z-scores of attention,memory,visuospatial ability and language function subdomains in pPD-MCI group were significantly decreased(P<0.05-0.01).Multivariate Logistic regression analysis showed that high UPDRS Ⅲ score was an independent risk factor for Ppd-MCI(OR=0.799,95%CI:0.680-0.938,P=0.006).Conclusions The motor symptoms of Ppd-MCI patients are more severe than those of Ppd-NC patients.Memory,visuospatial ability and language function are the main cognitive impairment domains.High UPDRS Ⅲ score is an independent risk factor for Ppd cognitive impairment.关键词
帕金森病/前驱期/轻度认知障碍Key words
Parkinson's disease/prodromal stage/mild cognitive impairment分类
医药卫生引用本文复制引用
尹行行,顾昊,刘卫国,张书刚..帕金森病前驱期轻度认知障碍患者认知域损害特征及危险因素分析[J].临床神经病学杂志,2024,37(4):278-282,5.基金项目
国家重点研发计划重点专项(2017YFC1310300,2017YFC1310302) （2017YFC1310300,2017YFC1310302）
国家自然科学基金资助项目(81571348) （81571348）
江苏省重点研发计划专项资金项目(BE2019611) （BE2019611）
江苏省自然科学基金项目(BK20151077) （BK20151077）
