临床神经外科杂志2024，Vol.21Issue(4)：361-364,370,5.DOI:10.3969/j.issn.1672-7770.2024.04.001
浅谈颅脑外伤精准诊疗与分子标志物
Brief discussion on precise diagnosis and treatment of craniocerebral trauma and molecular markers
摘要
Abstract
Traumatic brain injury(TBI)is a major cause of injury-related death and disability,and its treatment and prognosis evaluation present challenges.The heterogeneity of TBI complicates diagnostic and therapeutic strategies,considering factors such as injury nature,timing,and severity.Several comprehensive guidelines currently guide the entire process of TBI management.However,there are still controversies regarding surgical timing and intervention methods,prognosis accuracy,and imaging checkpoints.Both overly conservative and overly aggressive decisions can impact patients and their families.With the rapid development of biological technologies in recent years,an increasing number of biomolecular markers have proven to be significant in TBI assessment.Current TBI prognosis models provide clinical references,and further integration with biomarkers and other clinical characteristics may enhance predictive accuracy.Future advancements in single-cell genomics,metabolomics,and the establishment of large-scale clinical databases are expected to drive precision medicine in TBI,improving personalized treatment strategies and outcomes.关键词
颅脑外伤/分子标志物/精准诊疗/预后模型Key words
traumatic brain injury/molecular marker/precision medical care/prognostic modeling分类
医药卫生引用本文复制引用
季晶..浅谈颅脑外伤精准诊疗与分子标志物[J].临床神经外科杂志,2024,21(4):361-364,370,5.基金项目
国家自然科学基金项目(82120108018) （82120108018）
