临床误诊误治2024，Vol.37Issue(13)：62-65,70,5.DOI:10.3969/j.issn.1002-3429.2024.13.013
高通量低钙血液透析对老年尿毒症患者血清MCP-1、β2-MG水平及尿素清除指数的影响
Effects of High-flux Low-calcium Hemodialysis on Serum MCP-1,β2-MG and Urea Clearance Index in Elderly Patients with Uremia
摘要
Abstract
Objective To analyze the efficacy of high-flux low-calcium hemodialysis in the treatment of elderly pa-tients with uremia.Methods In total,380 elderly patients with uremia treated from December 2017 to June 2022 were se-lected and divided into control group and observation group by random number table method,with 190 patients in each group.The control group received low-flux hemodialysis,and the observation group received high-flux low-calcium hemodialysis.The renal function[serum creatinine(Scr),blood urea nitrogen(BUN),β2-microglobulin(β2-MG)],monocyte chemoattrac-tant protein-1(MCP-1),serum calcium and phosphorus metabolism indexes and urea clearance index(Kt/V)of the two groups were compared.Results The total effective rate of observation group was 92.63%,which was higher than that of con-trol group(73.68%)(P＜0.05).After treatment,the levels of Scr,BUN,β2-MG,MCP-1,serum calcium and serum phosphorus in observation group were decreased compared with those in control group(P＜0.05).Kt/V in the observation group was increased as compared with that in the control group(P＜0.05).There was no significant difference in the inci-dence of adverse reactions between the two groups(P＞0.05).Conclusion High-flux low-calcium hemodialysis is an ideal treatment option for elderly patients with uremia,which can obviously reduce serum MCP-1 level and increase Kt/V,and has high clinical application value.关键词
尿毒症/高通量血液透析/低钙透析液/低通量血液透析/老年/单核细胞趋化蛋白-1/β2-微球蛋白/尿素Key words
Uremia/High-flux hemodialysis/Low-calcium dialysate/Low-flux hemodialysis/Elderly/Monocyte chemoattractant protein-1/β2-microglobulin/Urea nitrogen分类
医药卫生引用本文复制引用
孔子昂,葛郡,袁娟..高通量低钙血液透析对老年尿毒症患者血清MCP-1、β2-MG水平及尿素清除指数的影响[J].临床误诊误治,2024,37(13):62-65,70,5.基金项目
黑龙江省卫生健康委科研课题(20230303050501) （20230303050501）
