临床小儿外科杂志2024，Vol.23Issue(7)：697-700,4.DOI:10.3760/cma.j.cn101785-202207041-018
肾母细胞瘤胚胎学起源的研究进展
Research advances in embryological origin of Wilms tumor
摘要
Abstract
Characterized by multiple congenital anomalies,nephroblastoma(Wilms tumor,WT)is the most common renal malignancy in children.Embryonic kidney has at least three lineage-specific progenitor cells.Usually lost before birth,these cells with nephrogenic residue persist in WT.Therefore WT is an embryon-ic tumor reproducing the histological growth pattern of kidney.As one kind of tumor cells with high differentia-tion potential,tumor stem cells are also closely correlated with the occurrence and development of WT.Thanks to mainstay surgery plus chemotherapy,5-year survival rate of early stage WT has surpassed 90％.However,some patients still die from tumor metastasis and recurrence.Therefore a thorough understanding the formation and regulation of developing kidney and in-depth exploring the origin of embryonic precursors of WT may pro-vide novel therapeutic strategies for managing WT.关键词
肾母细胞瘤/非编码RNA/甲基化/外科手术/儿童Key words
Wilms Tumor/Non-coding RNA/Methylation/Surgical Procedures,Operative/Child引用本文复制引用
覃善璐,董岿然..肾母细胞瘤胚胎学起源的研究进展[J].临床小儿外科杂志,2024,23(7):697-700,4.基金项目
唐仲英基金会项目(ZSBK0070) Project of Tang Zhongying Foundation(ZSBK0070) （ZSBK0070）
