环境与职业医学2024，Vol.41Issue(7)：828-833,6.DOI:10.11836/JEOM23448
生命早期空气污染物暴露与儿童神经发育障碍的研究进展
Research progress on relationship between air pollutant exposure during early life and neu-rodevelopmental disorders in children
摘要
Abstract
In recent years,the effects of air pollutants on the neurodevelopmental disorders in children have received widespread attention.Early life is a critical period of rapid brain development,and exposure to air pollutants during this period may permanently alter brain function.This paper reviewed the epidemiological studies on the association between exposure to air pollutants during early life and children's neurodevelopmental disorders in recent years,with focus on outdoor air pollutants(e.g.,PM2.5,PM10,NOx,and CO)and indoor air pollutants(e.g.,cooking oil fumes,to-bacco and mosquito incense smoke,and formaldehyde from home decoration),and summarized their possible biological mechanisms.Most studies indicate that pollutants in different periods and at different levels of exposure during early life can negatively affect children's neurodevel-opment and that there may be a dose-response relationship between certain air pollutants and children's neurodevelopment.Current research on the effects of indoor air pollutants on children's neurodevelopment focus on exposure to tobacco smoke,while other indoor air pollutants such as cooking oil fumes and organic compounds produced by interior decorative materials are less well reported and their underlying biological mechanisms are not yet clear.Further epidemi-ological studies,animal and cellular experiments are needed to provide evidence for the neu-rodevelopmental toxicity of air pollutant exposure in the future,aiming to provide a theoretical basis for environmental eugenics and promote healthy development of children.关键词
神经发育障碍/儿童/室外空气污染/室内空气污染/生命早期暴露Key words
neurodevelopmental disorder/child/outdoor air pollution/indoor air pollution/early-life exposure分类
医药卫生引用本文复制引用
姜妍妍,童娟,陶芳标..生命早期空气污染物暴露与儿童神经发育障碍的研究进展[J].环境与职业医学,2024,41(7):828-833,6.基金项目
国家自然科学基金项目(82304167) （82304167）
安徽省高校自然科学研究项目(2023AH050559) （2023AH050559）
