上海针灸杂志2024，Vol.43Issue(8)：823-829,7.DOI:10.13460/j.issn.1005-0957.2024.08.0823
针刺联合中药耳浴治疗真菌性外耳道炎的疗效观察
Efficacy observation of acupuncture plus Chinese medicine ear bath for fungal otitis externa
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture plus Chinese medicine ear bath in treating fungal otitis externa.Method A total of 108 patients with fungal otitis externa were divided into an observation group and a control group using the random number table method,with 54 cases in each group.Both groups received Sertaconazole nitrate cream treatment.The control group received Chinese medicine ear bath,and the observation group received acupuncture plus Chinese medicine ear bath.The effect onset time,clinical efficacy,and relapse rate were compared between the two groups.Before and after the treatment,both groups were observed for changes in the symptom score of traditional Chinese medicine(TCM),itching score,erythrocyte sedimentation rate(ESR),serum inflammatory factor levels[interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)],and the relative expression of serum miR-210 and miR-146.Result The total effective rate was 92.2%in the observation group,higher than 82.4%in the control group,and the difference was statistically significant(P＜0.05).After the treatment,the serum inflammatory factor levels,TCM symptom score,and itching score dropped in both groups(P＜0.05)and were lower in the observation group than in the control group(P＜0.05).After the intervention,the relative expression of serum miR-146 declined in both groups(P＜0.05),and the relative expression of serum miR-210 increased(P＜0.05);the expression level of miR-146 was lower in the observation group than in the control group,and the level of miR-210 was higher in the observation group(P＜0.05).The average effect onset time was earlier in the observation group compared to the control group(P＜0.05),and the observation group had a lower relapse rate(P＜0.05).Conclusion Based on the external application of Sertaconazole nitrate cream,acupuncture plus Chinese medicine ear bath can produce more significant clinical efficacy than Chinese ear bath in treating fungal otitis externa,working faster with fewer relapses.This method can effectively improve itching symptoms and regulate serum inflammatory factor levels and the relative expression of serum miR-210 and miR-146.关键词
针刺疗法/针药并用/薰洗/外耳道炎/真菌感染/瘙痒/白介素-6/肿瘤坏死因子-αKey words
Acupuncture therapy/Acupuncture medication combined/Steaming washing therapy/Otitis externa/Fungal infection/Itching/Interleukin-6/Tumor necrosis factor-α分类
医药卫生引用本文复制引用
刘娟,帕茹克·鲁提夫拉,赵翠宏,马忠..针刺联合中药耳浴治疗真菌性外耳道炎的疗效观察[J].上海针灸杂志,2024,43(8):823-829,7.基金项目
新疆医科大学大学生创新训练计划项目(CX2020004) （CX2020004）
