上海针灸杂志2024，Vol.43Issue(8)：891-897,7.DOI:10.13460/j.issn.1005-0957.2024.08.0891
针刺联合中药治疗儿童癫痫的疗效观察及对脑电图和智力水平的影响
Observation on the efficacy of acupuncture combined with Chinese herbal medicines in the treatment of epilepsy in children and its effect on EEG and intelligence level
摘要
Abstract
Objective To observe the clinical efficacy of acupuncture combined with Dian Xian Cu Xiao formula in the treatment of childhood epilepsy and its effect on patients'EEG and intelligence level.Method A total of 80 pediatric epilepsy patients were randomly divided into a control group(40 cases)and a study group(40 cases).The control group was treated with conventional antiepileptic therapy,while the study group was treated with acupuncture combined with Dian Xian Cu Xiao formula on the basis of the treatment in the control group.The clinical efficacy,improvement rate of electroencephalogram(EEG)and incidence of adverse effects were compared between the two groups,and the seizure situation(seizure frequency and symptom duration),traditional Chinese medicine(TCM)syndrome score,mini-mental state examination(MMSE)score and Wechsler intelligence scale for children-revised in China(WLSC-CR)were observed before and after the treatment in both groups,and the changes of serum inflammatory factors and cognitive impairment related indexes were observed before and after treatment in the two groups.Result The total effective rate of the study group was higher than that of the control group(P＜0.05),and the improvement rate of EEG was higher than that of the control group(P＜0.05).After 1-month treatment and after treatment,the frequency of seizures in the study group was lower than that of the control group(P＜0.05),the duration of symptoms was shorter than that of the control group(P＜0.05),the TCM syndrome score was lower than that of the control group(P＜0.05),and the total,verbal,and operative intelligence scores in the WLSC-CR scores were higher than that of the control group(P＜0.05),and the MMSE scores were higher than that of the control group(P＜0.05).After 1-month treatment and after treatment,serum malondialdehyde(MDA),interleukin-1β(IL-1β),interleukin-6(IL-6),high mobility group box-1(HMGB1)and matrix metalloprotein-9(MMP-9)levels were lower than those of the control group(P＜0.05),and the levels of serum superoxide dismutase(SOD)and aquaporin 4(AQP4)were higher than those of the control group(P＜0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P＞0.05).Conclusion On the basis of conventional antiepileptic treatment,acupuncture combined with Dian Xian Cu Xiao formula for the treatment of epilepsy in children can improve the clinical efficacy,reduce the frequency of epileptic seizures,shorten the duration of epileptic seizures,improve the EEG,improve the intellectual level of the patients,and down-regulate inflammatory response and stress response.关键词
针刺疗法/针药并用/癫痫/儿童/智力/脑电图/炎症反应/应激反应Key words
Acupuncture therapy/Acupuncture medication combined/Epilepsy/Children/Intelligence/Electroencephalography/Inflammatory response/Stress response分类
医药卫生引用本文复制引用
任莉,万鸽,李孟,谢小培,张靖..针刺联合中药治疗儿童癫痫的疗效观察及对脑电图和智力水平的影响[J].上海针灸杂志,2024,43(8):891-897,7.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20191453) （LHGJ20191453）
