妇儿健康导刊2024，Vol.3Issue(15)：190-194,5.
南宁市某妇幼医院重症肺炎支原体肺炎感染患儿临床特征及耐药性分析
Analysis of clinical characteristics and drug resistance of children with severe Mycoplasma pneumoniae pneumonia infection in a Nanning Maternal and Child Health Hospital
摘要
Abstract
Objective To analyze the clinical characteristics and drug resistance of children with severe Mycoplasma pneumoniae pneumonia(SMPP)infection in Nanning Maternity and Child Health Hospital.Methods The clinical data of 122 children with SMPP infection admitted to Nanning Maternity and Child Health Hospital from August to November 2023 were collected and analyzed.According to the results of drug resistance gene detection,they were divided into drug resistance group(n=60)and non-drug resistance group(n=62).The resistance genes of Mycoplasma pneumoniae to macrolide antibiotics in bronchoalveolar lavage fluid were detected by passive agglutination and fluorescent PCR,and their clinical characteristics and drug resistance were analyzed.Results The clinical characteristics of SMPP children were mainly high fever or ultra-high fever,accompanied by paroxysmal cough,fever time<7 days,and most of the pulmonary moist rales.There were statistically significant differences in hospitalization days,alanine aminotransferase,and total days of fever duration between the two groups(P<0.05).There was statistically significant difference in the use of hormones and Doxycycline between the two groups(P<0.05).There was no significant difference in the incidence of emphysema,atelectasis,pulmonary abscess,pleural effusion,and plastic bronchitis between the two groups(P>0.05).There were significant differences in the levels of immunoglobulin(Ig)A,IgM,and total IgE between the two groups(P<0.05).Conclusion Children infected with SMPP are more sensitive to hormone and Doxycycline drug resistance,and the bronchoscopic manifestations and clinical characteristics of drug-resistant children are more obvious,and the level of related Ig in drug-resistant children is higher.In clinical diagnosis and treatment,close attention should be paid to the occurrence and development of drug resistance in children.关键词
重症肺炎支原体肺炎/儿童/临床特征/支气管肺泡灌洗液/耐药性Key words
Severe Mycoplasma pneumoniae pneumonia/Children/Clinical characteristic/Bronchoalveolar lavage fluid/Drug resistance分类
医药卫生引用本文复制引用
盘玲玲,黄树稳,颜云盈,蓝羚榕..南宁市某妇幼医院重症肺炎支原体肺炎感染患儿临床特征及耐药性分析[J].妇儿健康导刊,2024,3(15):190-194,5.基金项目
广西壮族自治区卫生健康委自筹经费科研课题(Z-A20231247). （Z-A20231247）
