右江医学2024，Vol.52Issue(7)：591-598,8.DOI:10.3969/j.issn.1003-1383.2024.07.003
老年营养风险指数与进展期非小细胞肺癌患者预后的相关性分析
Analysis on association between geriatric nutritional risk index and prognosis of advanced non-small cell lung cancer patients
摘要
Abstract
Objective To investigate the relevance of geriatric nutritional risk index(GNRI)on the prognosis of patients with advanced non-small cell lung cancer(NSCLC).Methods A total of 117 elderly advanced NSCLC patients with nega-tive driver gene who were diagnosed in the Department of Medical Oncology of the People's Hospital of Guangxi Zhuang Au-tonomous Region from January 2017 to December 2021 were retrospectively analyzed.The baseline data of the patients,labo-ratory test results,and imaging findings were collected,and the survival status of the patients were followed up through vari-ous methods.Results Compared with the high GNRI group(GNRI＞98,n=35),patients in the low GNRI group(GNRI≤98,n=82)were more likely to experience pleural metastasis and decreased albumin,and difference between the two groups was statistically significant(P＜0.05).According to the Kaplan Meier curve,the low GNRI group had worse progression free survival(9 months vs 19 months,P＜0.001)and overall survival(16 months vs 41 months,P＜0.001).Univariate and multivariate analyses showed that low GNRI was an independent risk factor for overall survival(P＜0.05).Conclusion GNRI is a simple and effective potential predictor of outcome and survival in elderly patients with progressive NSCLC,and low GNRI may be associated with worse prognosis.关键词
进展期肺癌/老年营养风险指数/预后/生存分析Key words
advanced lung cancer/geriatric nutritional risk index(GNRI)/prognosis/survival analysis分类
临床医学引用本文复制引用
高珊,吕艳茹,谢嫣嫣,黄琴,陈晓丹,陆水,竺建芳,蒿艳蓉..老年营养风险指数与进展期非小细胞肺癌患者预后的相关性分析[J].右江医学,2024,52(7):591-598,8.基金项目
广西重点研发计划项目(桂科-AB21196012) （桂科-AB21196012）
广西卫健委自筹经费科研课题(Z20210544) （Z20210544）
