摘要
Abstract
Objective To explore the effectiveness of pramipexole tablets combined with dopazazine tablets in the treat-ment of Parkinson's disease(PD)and its effects on activated T cell chemokines(RANTES)and α-synuclein(α-syn).Methods A total of 84 patients with PD admitted to Luoyang Oriental People's Hospital from April 2019 to September 2021 were selected as research objects.They were divided into control group and combination group by random number table,with 42 cases in each group.The control group were given dopamazide tablets,and the combination group were given pramexol tablets on this basis.And then,clinical efficacy as well as the Comprehensive Parkinson's Disease Scale(UPDRS),Mont-real Cognitive Assessment(MoCA)Scale,Activity of Daily Living(ADL)Scale,P300(latency,amplitude),disease-re-lated indicators(interleukin-6[IL-6],interleukin-1β[IL-1β],RANTES,α-syn)before treatment,at 1 month and 3 months after treatment,and adverse reactions of the two groups were compared.Results The total effective rate of the com-bination group was 95.24%,which was higher than that of the control group(78.58%)(P＜0.05).Compared with the control group,after 1 month and 3 months of treatment,the UPDRS scores of the combination group were significantly de-creased,while the MoCA and ADL scores were significantly increased(P＜0.05).Compared with those before treatment,the P300 latency of the two groups was significantly shortened,and the amplitude of the wave was significantly increased after 1 month and 3 months of treatment,and change in the combination group was even more significant(P＜0.05).Compared with those before treatment,serum levels of IL-6,IL-1β,RANTES and α-syn in the two groups were decreased continuously after 1 month and 3 months of treatment,especially in the combination group(P＜0.05).The incidence of adverse reactions in the combination group was 11.90%,compared with 7.14%in the control group,the difference was not statistically signifi-cant(P＞0.05).Conclusion Dopamazid tablets combined with pramexol tablets are effective in the treatment of PD,which can effectively improve the neurological function and cognitive function of patients,reduce inflammation,relieve the disease,and improve the quality of life.关键词
多巴丝肼片/普拉克索片/帕金森病/神经功能/认知功能/P300Key words
dopaminazide tablets/pramexol tablets/Parkinson's disease(PD)/neurological function/cognitive func-tion/P300分类
医药卫生
