Targeting the chromatin structural changes of antitumor immunityOA
Targeting the chromatin structural changes of antitumor immunity
Epigenomic imbalance drives abnormal transcriptional processes,promoting the onset and progression of cancer.Although defective gene regulation generally affects carcinogenesis and tumor suppression networks,tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes,which may have significant implications for the development and application of epigenetic therapy,cancer immunotherapy,and their combinations.Herein,we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes,DNA methylation,histone post-translational modification,and chromatin structure in tumor immunogenicity,and introduce these epigenetic research methods.We emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immuno-therapy through the complex interaction between cancer epigenetics and cancer immunology.
Nian-nian Li;Kewei Hu;Lala Li;Si-ying Li;Wenbo Liu;Wanping Zhu;Yunlong Zhang;Jikai Li;Ting Yao;Leming Mou;Xiaoqing Han;Deng-xing Lun;Furong Hao;Yongcheng Hu;Lin Liu;Hongguang Zhu;Yuyun Wu;Bin Liu;Ningning Gong;Gang Meng;Xin-ying Du;He Wang;Xiangxiang Bao;Xin-yang Li;Ji-wu Song
Weifang People's Hospital,Weifang,Shandong,261000,China||School of Life Sciences,Nankai University,Tianjin,300071,ChinaWeifang Traditional Chinese Medicine Hospital,Weifang,Shandong,261000,ChinaGuizhou Normal University,Guiyang,550025,ChinaWeifang People's Hospital,Weifang,Shandong,261000,ChinaSchool of Medical Imaging,Weifang Medical University,Weifang,Shandong,261053,ChinaDepartment of Bone and Soft Tissue Oncology,Tianjin Hospital,Tianjin,300299,ChinaSchool of Life Sciences,Nankai University,Tianjin,300071,China||Teda Institute of Biological Sciences & Biotechnology,Nankai University,Tianjin,300457,ChinaSchool of Life Sciences,Nankai University,Tianjin,300071,ChinaXinqiao Hospital of Army Military Medical University,Chongqing,400038,ChinaWeifang People's Hospital,Weifang,Shandong,261000,China||School of Life Sciences,Nankai University,Tianjin,300071,China||Teda Institute of Biological Sciences & Biotechnology,Nankai University,Tianjin,300457,ChinaShaanxi Key Laboratory of Sericulture,Ankang University,Ankang,Shaanxi,725000,ChinaGuizhou Education University,Guiyang,550018,China
Antitumor immunityChromatin structuralCancer epigeneticsDNA methylationHistone modificationChemotherapy
《药物分析学报（英文）》 2024 (004)
460-482 / 23
This study was supported by the Startup Foundation for Junior Faculty,Nankai University(Grant No.:63191439),the National Natural Science Foundation of China(Grant Nos.:32100418 and 3210040345),The Health Commission Foundation of China(Grant No.:2018ZX10712001-017)and the Chongqing Medical College Natural Fund(Grant Nos.:ygz2019302 and ygz2019305).
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