An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in strokeOA
An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke
A two-photon near infrared(NIR)fluorescence turn-on sensor with high selectivity and sensitivity for Zn2+detection has been developed.This sensor exhibits a large Stokes'shift(-300 nm)and can be excited from 900 to 1000 nm,with an emission wavelength of-785 nm,making it ideal for imaging in biological tissues.The sensor's high selectivity for Zn2+over other structurally similar cations,such as Cd2+,makes it a promising tool for monitoring zinc ion levels in biological systems.Given the high concentration of zinc in thrombi,this sensor could provide a useful tool for in vivo thrombus imaging.
Junfeng Wang;Qibing Liu;Yingbo Li;Yi Pang
Department of Chemistry,The University of Akron,Akron,OH 44325,USA||Gordon Center for Medical Imaging,Department of Radiology,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,USADepartment of Pharmacy,The First Affiliated Hospital of Hainan Medical University,Haikou,570100,China||Engineering Research Center of Tropical Medicine,Ministry of Education,Hainan Medical University,Haikou,571199,ChinaState Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing,100191,ChinaDepartment of Chemistry,The University of Akron,Akron,OH 44325,USA||Maurice Morton Institute of Polymer Science,The University of Akron,Akron,OH 44325,USA
Near-infraredMolecular imagingThrombusStroke
《药物分析学报（英文）》 2024 (004)
578-584 / 7
This work was supported by the National Institute of Health(Grant Nos.:1R15EB014546-01A1 and K25AG061282).We also thank the Coleman endowment from the University of Akron for partial support.
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