Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in miceOA
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
The"gut-skin"axis has been proved and is considered as a novel therapy for the prevention of skin aging.The antioxidant efficacy of oligomannonic acid(MAOS)makes it an intriguing target for use to improve skin aging.The present study further explored whereby MAOS-mediated gut-skin axis balance prevented skin aging in mice.The data indicated the skin aging phenotypes,oxidative stress,skin mitochondrial dysfunction,and intestinal dysbiosis(especially the butyrate and HIF-1 α levels decreased)in aging mice.Similarly,fecal microbiota transplantation(FMT)from aging mice rebuild the aging-like phenotypes.Further,we demonstrated MAOS-mediated colonic butyrate-HIF-1α axis homeostasis promoted the entry of butyrate into the skin,upregulated mitophagy level and ultimately improving skin aging via HDAC3/PHD/HIF-1α/mitophagy loop in skin of mice.Overall,our study offered a better insights of the effectiveness of alginate oligosaccharides(AOS),promised to become a personalized targeted therapeutic agents,on gut-skin axis disorder inducing skin aging.
Ting Gao;Yixuan Li;Xiaoyu Wang;Fazheng Ren
Department of Nutrition and Health,College of Veterinary Medicine,China Agricultural University,Beijing,100083,China
Alginate oligosaccharideSkin agingButyrateHIF-1αMitophagy
《药物分析学报(英文)》 2024 (005)
678-692 / 15
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