Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyondOA
Bio-soft matter derived from traditional Chinese medicine:Characterizations of hierarchical structure,assembly mechanism,and beyond
Structural and functional explorations on bio-soft matter such as micelles,vesicles,nanoparticles,ag-gregates or polymers derived from traditional Chinese medicine(TCM)has emerged as a new topic in the field of TCM.The discovery of such cross-scaled bio-soft matter may provide a unique perspective for unraveling the new effective material basis of TCM as well as developing innovative medicine and biomaterials.Despite the rapid rise of TCM-derived bio-soft matter,their hierarchical structure and as-sembly mechanism must be unambiguously probed for a further in-depth understanding of their pharmacological activity.In this review,the current emerged TCM-derived bio-soft matter assembled from either small molecules or macromolecules is introduced,and particularly the unambiguous elucidation of their hierarchical structure and assembly mechanism with combined electron microscopic and spectroscopic techniques is depicted.The pros and cons of each technique are also discussed.The future challenges and perspective of TCM-derived bio-soft matter are outlined,particularly the requirement for their precise in situ structural determination is highlighted.
Guiya Yang;Yue Liu;Yuying Hu;Yue Yuan;Yunan Qin;Quan Li;Shuangcheng Ma
School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,ChinaTianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine,School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin,301617,ChinaCollaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry,Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules,College of Chemistry and Chemical Engineering,Hubei University,Wuhan,430062,ChinaSchool of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China||Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing 100050,China
Electron microscopySpectroscopyTraditional Chinese medicineBio-soft matterStructural characterization
《药物分析学报（英文）》 2024 (006)
823-839 / 17
This work was supported by the National Natural Science Foundation of China(Grant No.:82374033 and 21901067),Ministry of Science and Technology of China(Grant No.:2023YFC3504100),and Starting Grant from the Ministry of Human Resource and Social Security of China(Quan Li).
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