医药导报2024，Vol.43Issue(9)：1429-1434,6.DOI:10.3870/j.issn.1004-0781.2024.09.012
丙戊酸钠治疗成人癫痫合并非酒精性脂肪性肝病的临床研究进展
Progress of Clinical Studies on the Use of Sodium Valproate in Adult Patients with Epilepsy Combined with Nonalcoholic Fatty Liver Disease
摘要
Abstract
Epilepsy patients are prone to obesity and metabolic syndrome(MetS),which is a higher risk than the general population.Nonalcoholic fatty liver disease(NAFLD)is a manifestation of a metabolic syndrome,characterized by hepatic steatosis,which can be exacerbated to some extent in patients with epilepsy.Sodium valproate(VPA),a commonly used clinical antiepileptic drug,leads to triglyceride accumulation in liver cells and induces a risk of NAFLD.In adults with epilepsy combined with NAFLD,treatment with VPA can make the liver,which is already affected by steatosis,more sensitive to VPA-induced liver injury and affect VPA drug metabolism.Both VPA and NAFLD induce hepatic steatosis,and can exacerbate each other's induced hepatic steatosis synergistically during epilepsy treatment.In this paper,we reviewed the progress of clinical studies on the use of VPA in adult patients with epilepsy combined with NAFLD to provide references for effective treatment and future studies of VPA.关键词
丙戊酸钠/癫痫/非酒精性脂肪性肝病Key words
Sodium valproate/Epilepsy/Nonalcoholic fatty liver disease分类
药学引用本文复制引用
尹争,李沛,李柯婧,王爱元,季倩倩..丙戊酸钠治疗成人癫痫合并非酒精性脂肪性肝病的临床研究进展[J].医药导报,2024,43(9):1429-1434,6.基金项目
中国抗癫痫协会癫痫科研基金资助项目(2020014B). （2020014B）
