医药导报2024，Vol.43Issue(9)：1451-1456,6.DOI:10.3870/j.issn.1004-0781.2024.09.016
肾脏转运体在多黏菌素肾毒性中的研究进展
Research Progress of Renal Transporters in Polymyxin-induced Nephrotoxicity
周思敏 1罗雪梅 2成硕 1葛卫红3
作者信息
- 1. 中国药科大学南京鼓楼医院药学部,南京 210008||中国药科大学基础医学与临床药学学院,南京 210009
- 2. 南京大学医学院附属鼓楼医院药学部,南京 210008
- 3. 中国药科大学南京鼓楼医院药学部,南京 210008||南京大学医学院附属鼓楼医院药学部,南京 210008
- 折叠
摘要
Abstract
Polymyxins are the first-line drugs used in multidrug resistance(MDR)Gram-negative infections.Polymyxin-induced nephrotoxicity is the major dose-limiting factor hindering its clinical use.It has been suggested that the mechanism of polymyxin-associated nephrotoxicity is related to its accumulation in the kidney upon extensive reabsorption from renal proximal tubular cells,and one or more renal transporters may mediate the process that polymyxins enter the renal tubular cells across cytomembrane.This review aimed to describe the roles of renal transporters in polymyxins reabsorption into the renal tubular cells and provide reference for reducing the nephrotoxicity of polymyxin.关键词
多黏菌素/肾毒性/肾脏转运体/巨蛋白Key words
Polymyxin/Nephrotoxicity/Renal transporters/Megalin分类
药学引用本文复制引用
周思敏,罗雪梅,成硕,葛卫红..肾脏转运体在多黏菌素肾毒性中的研究进展[J].医药导报,2024,43(9):1451-1456,6.
