针刺研究2024，Vol.49Issue(8)：851-857,866,8.DOI:10.13702/j.1000-0607.20230031
针刺调控微小RNA治疗缺血性脑卒中机制的研究进展
Progress of researches on the mechanisms of acupuncture intervention underlying improvement of ischemic stroke by regulating microRNAs
摘要
Abstract
MicroRNAs play an important role in the occurrence and development of ischemic stroke(IS).A lot of researches have shown that acupuncture intervention can improve IS-induced neural dysfunction by regulating miRNA.In the present paper,we summarized the current progress of researches on the mechanisms of acupuncture underlying improvement of IS via regulation of miRNA from 1)promoting angiogenesis and increasing cerebral blood flow,2)inhibiting inflammatory response,3)maintaining blood-brain barrier homeostasis and relieving brain edema,4)regulating programmed cell death,5)promoting neuron regeneration,and 6)improving synaptic plasticity.These miRNA-related mechanisms may provide a reference for the follow-up research.关键词
针刺/微小RNA/缺血性脑卒中/作用机制/综述Key words
Acupuncture/MicroRNA/Ischemic stroke/Mechanism/Review引用本文复制引用
李成龙,茅伟,张利达,韩为,张鑫,王颖..针刺调控微小RNA治疗缺血性脑卒中机制的研究进展[J].针刺研究,2024,49(8):851-857,866,8.基金项目
国家自然科学基金项目(No.81973933) （No.81973933）
安徽省第十三批115产业创新团队项目[No.皖人才办(2020)4号] （2020）
安徽省针灸临床医学研究中心项目(No.2021zjzx02) （No.2021zjzx02）
安徽省名中医王颖工作室建设项目[No.中发展(2022)5号] （2022）
