针刺调控微小RNA治疗缺血性脑卒中机制的研究进展OA北大核心CSTPCDMEDLINE
Progress of researches on the mechanisms of acupuncture intervention underlying improvement of ischemic stroke by regulating microRNAs
微小RNA(miRNA)参与调节缺血性脑卒中(IS)的发生发展.针刺可通过调控miRNA改善IS神经功能缺损,其作用机制与促进血管新生、抑制炎性反应、维持血脑屏障、调节细胞程序性死亡、促进神经元再生和提高突触可塑性等方面有关.本文回顾总结了针刺调控miRNA治疗IS的机制研究现状,以期为后续研究提供参考.
MicroRNAs play an important role in the occurrence and development of ischemic stroke(IS).A lot of researches have shown that acupuncture intervention can improve IS-induced neural dysfunction by regulating miRNA.In the present paper,we summarized the current progress of researches on the mechanisms of acupuncture underlying improvement of IS via regulation of miRNA from 1)promoting angiogenesis and increasing cerebral blood flow,2)inhibiting inflammatory response,3)maintaining blood-brain barrier homeostasis and relieving brain edema,4)regulating programmed cell death,5)promoting neuron regeneration,and 6)improving synaptic plasticity.These miRNA-related mechanisms may provide a reference for the follow-up research.
李成龙;茅伟;张利达;韩为;张鑫;王颖
安徽中医药大学第一临床医学院,合肥 230012广州医科大学附属脑科医院,广州 510370南京市高淳区中医院针灸科,南京 211300安徽中医药大学第二附属医院,合肥 230061
针刺微小RNA缺血性脑卒中作用机制综述
AcupunctureMicroRNAIschemic strokeMechanismReview
《针刺研究》 2024 (008)
851-857,866 / 8
国家自然科学基金项目(No.81973933);安徽省第十三批115产业创新团队项目[No.皖人才办(2020)4号];安徽省针灸临床医学研究中心项目(No.2021zjzx02);安徽省名中医王颖工作室建设项目[No.中发展(2022)5号]
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