中国临床药理学杂志2024，Vol.40Issue(15)：2261-2264,4.DOI:10.13699/j.cnki.1001-6821.2024.15.023
基于网络药理学与分子对接探讨芍药苷治疗糖尿病的作用
Role of paeoniflorin in the treatment of diabetes based on network pharmacology and molecular docking
摘要
Abstract
Objective To explore the potential mechanism of action of paeoniflorin in diabetes mellitus,the related targets and pathways were preliminarily discussed,based on the network pharmacology and molecular docking technology.Methods Analyze the potential targets of paeoniflorin using the Swiss Target Prediction database.Genecards and OMIM databases yielded the genes of diabetes-related illnesses.After taking the intersection of the two,protein-protein interaction network(PPI)was established using STRING and Cytoscape programs to search for key genes with strong correlation and complete gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.Use AutoDockTools and Pymol programs to complete protein molecule docking validation.Results The pharmacologically-related study revealed 63 targets associated with paeoniflorin,4 758 genes related to diabetes,and 50 intersection targets.15 key genes including vascular endothelial growth factor A(VEGFA),epidermal growth factor receptor(EGFR),V-Ha-ras harvey(HRAS),V-src sarcoma(SRC)and heat shock protein hs 90-alpha(HSP90AA1)were screened.RAs-associated protein 1,Ras,calcium and other signaling pathways were obtained by KEGG pathway analysis.Molecular docking results showed that paeoniflorin had good binding ability with key genes.Conclusion Paeoniflorin can treat diabetes through multiple targets and pathways,and this mechanism can provide a basis for the application of paeoniflorin in anti diabetes and drug research and development.关键词
芍药苷/网络药理学/糖尿病/分子对接Key words
Paeoniflorin/network pharmacology/diabetes mellitus/molecular docking分类
医药卫生引用本文复制引用
宋思瑶,陆彭,伍鼎骁,康达,何雨惠,吕莹,林岩..基于网络药理学与分子对接探讨芍药苷治疗糖尿病的作用[J].中国临床药理学杂志,2024,40(15):2261-2264,4.基金项目
国家自然科学基金资助项目(82074148) （82074148）
国家级大学生创新创业训练基金资助项目(202211230036) （202211230036）
黑龙江省大学生创新创业训练基金资助项目(S202211230045) （S202211230045）
