中国临床药理学杂志2024，Vol.40Issue(15)：2278-2282,5.DOI:10.13699/j.cnki.1001-6821.2024.15.027
铁死亡与肾纤维化相关性的研究现状
Research status of the correlation between ferroptosis and renal fibrosis
摘要
Abstract
Renal fibrosis is a common pathological manifestation of all chronic kidney diseases.Ferroptosis is closely related to the pathogenesis of renal fibrosis and can influence the onset of renal fibrosis,and it is the most critical step in the development of renal fibrosis.The paper describes the relationship between ferroptosis and renal fibrosis,discusses the research progress of ferroptosis on renal fibrosis,and further summarizes,analyzes,and describes the effective and highly targeted natural active ingredients of traditional Chinese medicines against ferroptosis,and concludes that the reversal of renal fibrosis is achieved through the regulation of the key targets of ferroptosis,with a view to providing a broad new direction for its prospects in the field of renal fibrotic disease prevention and treatment;and to provide a scientific guide for clinical treatment and basis for clinical treatment.关键词
铁死亡/肾纤维化/慢性肾病/发病机制/治疗Key words
ferroptosis/renal fibrosis/chronic kidney disease/pathogenesis/treatment分类
医药卫生引用本文复制引用
梁丽娟,戴恩来,白俊嫄,刘灿,丁昭然,张杰..铁死亡与肾纤维化相关性的研究现状[J].中国临床药理学杂志,2024,40(15):2278-2282,5.基金项目
国家自然科学基金资助项目(8216140859) （8216140859）
甘肃省高等学校创新基金资助项目(2022B-118) （2022B-118）
敦煌医学与转化教育部重点实验室基金资助项目(DHXY20-08) （DHXY20-08）
