中国临床药理学杂志2024，Vol.40Issue(15)：2292-2295,4.DOI:10.13699/j.cnki.1001-6821.2024.15.030
内质网-线粒体互扰在功能性消化不良中的机制及疏肝健脾类中药的干预现状
Mechanism of endoplasmic reticulum and mitochondria interference in functional dyspepsia and intervention status of Chinese medicine for Shu Gan Jian Pi
摘要
Abstract
Gastrointestinal dyskinesia is a central factor contributing to the development of functional dyspepsia(FD),which is characterized by the rupture of the gastrointestinal nerve-Cajal interstitial cell-smooth muscle network.Gan Yu Pi Xu are similar to endoplasmic reticulum stress(ERs)-mitochondrial autophagy homeostasis imbalance.Mitochondrial autophagy disorders are the biological basis of Pi Xu,and Gan Yu is the macroscopic manifestation of ERs,and regulation of ERs-mitochondrial autophagy pathway is an important way to prevent and control FD.In this paper,we start from the theory of"liver-spleen correlation",combine the changes of endoplasmic reticulum and mitochondria in the process of gastrointestinal dyskinesia,reveal the correlation between the pathogenesis of Gan Yu Pi Xu and the autophagy of ERs and mitochondria,and elucidate the mechanism of gastrointestinal dyskinesia by the method of Shu Gan Jian Pi,so as to provide a new point of view for the treatment of gastrointestinal dyskinesia in FD.关键词
内质网应激/线粒体自噬/功能性消化不良/肝郁脾虚Key words
endoplasmic reticulum stress/mitochondrial autophagy/functional dyspepsia/Gan Yu Pi Xu分类
医药卫生引用本文复制引用
郭军,武正权,王争艳,张慧君,李生财,田旭东..内质网-线粒体互扰在功能性消化不良中的机制及疏肝健脾类中药的干预现状[J].中国临床药理学杂志,2024,40(15):2292-2295,4.基金项目
甘肃省科技厅自然科学基金资助项目(21JR11RA206) （21JR11RA206）
甘肃省中医药管理局基金资助项目(qzkp-2021-14,GZK-2019-8) （qzkp-2021-14,GZK-2019-8）
