中国食品药品监管Issue(7)：134-145,12.DOI:10.3969/j.issn.1673-5390.2024.07.016
丹酚酸B多重护肤功效的综合评价
Comprehensive Evaluation of the Multiple Skin Care Effects of Salvianolic Acid B
龚旭 1田云才 2田勇 2张文环 2刘秋 1文燕 1徐学涛 1甘礼社3
作者信息
- 1. 五邑大学药学与食品工程学院
- 2. 上海致臻志臣科技有限公司
- 3. 五邑大学药学与食品工程学院||浙江中医药大学药学院
- 折叠
摘要
Abstract
Objective:This article systematically evaluates the multiple skincare activities of salvianolic acid B(Sal B)using non enzymatic glycosylation reaction models,human biochemical keratinocyte(HaCaT)cell photoaging models,collagen content determination in human embryonic skin fibroblasts(ESF),tyrosinase inhibition experiments,and cell tyrosinase inhibition experiments.Methods:The anti-glycation activity of Sal B was evaluated by nonenzymatic glycation reaction and the anti-aging activity of Sal B was evaluated by HaCaT cell photoaging model.The collagen content in human embryonic skin fibroblasts(ESF)was determined by sirius red-picric acid staining method,which determined the skin tightening activity of Sal B.The skin whitening effect of Sal B was evaluated by mushroom tyrosinase inhibition experiment and tyrosinase activity inhibition experiment in B16-F10 mouse melanoma cells.Combined with molecular docking,the sites of Sal B interacting with tyrosinase were predicted.Results:These results showed that Sal B could significantly inhibit the formation of advanced glycation end products(AGEs).It could also significantly enhance the viability of photoaging HaCaT cells by increasing the activity and content of endogenous antioxidants,including SOD and GSH.Sal B can also increase the content of collagen in ESF cells,thus exerting its skin tightening effect.Sal B can bind to tyrosinase through hydrogen bonds and hydrophobic interactions,significantly inhibiting its activity,thereby exerting a good skin whitening effect.Conclusion:In this paper,a variety of models were applied to evaluate the multiple skin care effects of Sal B,therefore providing a theoretical basis for the development and utilization of Sal B in skin care products.关键词
丹酚酸B/抗糖基化/抗光老化/抗氧化/美白/紧致皮肤Key words
salvianolic acid B/anti-glycation/anti-photoaging/antioxidant/skin whitening/skin tightening分类
化学化工引用本文复制引用
龚旭,田云才,田勇,张文环,刘秋,文燕,徐学涛,甘礼社..丹酚酸B多重护肤功效的综合评价[J].中国食品药品监管,2024,(7):134-145,12.
