20例ABO*AW.37等位基因增强现象的分析OACSTPCD
Analysis of ABO allelic enhancement phenomenon in 20 cases with ABO*AW.37 allele
目的 分析 20 例携带ABO*AW.37 等位基因的血清学和分子生物学特征,研究等位基因增强现象.方法 采用血清学方法检测ABO表型,对ABO基因 1～7 外显子采用Sanger测序进行基因型检测.结果 20 例测序均存在ABO*AW.37 的特征性变异c.940A>G(p.Lys314Glu).9 例ABO*AW.37 与B等位基因同时遗传时正定型抗-A均有凝集,血清学表型均为AwB.而11 例ABO*AW.37 与O基因同时遗传时正定…查看全部>>
Objective To investigate the serological and molecular characteristics of twenty blood samples carrying ABO∗AW.37 allele and to analyze ABO allelic enhancement.Methods The ABO phenotype of the twenty samples was de-termined by serological methods and the genotype of 1-7 ABO exons was analyzed by Sanger sequencing.Results Sequen-cing analysis showed that all twenty samples contained a c.940A>G(p.Lys314Glu)mutation of A allele,which was defined as ABO∗AW.37…查看全部>>
黄娴;李双玉;李彤彤;吴丽娜;解金辉;马蕾;种靖慧;安仕萍
天津市血液中心,天津 300110天津市血液中心,天津 300110天津市血液中心,天津 300110天津市血液中心,天津 300110天津市血液中心,天津 300110天津市血液中心,天津 300110天津市血液中心,天津 300110天津市血液中心,天津 300110
临床医学
ABO亚型ABO*AW.37等位基因增强基因测序
ABO subtypeABO*AW.37allelic enhancementgene sequencing
《中国输血杂志》 2024 (8)
886-889,4
天津市卫生健康委员会科技项目(TJWJ2021MS047)
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