中国输血杂志2024，Vol.37Issue(8)：890-895,939,7.DOI:10.13303/j.cjbt.issn.1004-549x.2024.08.008
血液病患者血小板输注无效的预测模型构建
Prediction model of platelet transfusion refractoriness in patients with hematological disorders
摘要
Abstract
Objective To explore the risk factors for platelet transfusion refractoriness(PTR)in patients with hemato-logical disorders,construct a prediction model and validate the model efficacy.Methods Patients with hematological disor-ders who received platelet transfusion therapy in the Chengdu Second People's Hospital from December 2021 to December 2022 were retrospectively included to judge the effectiveness of platelet transfusion and screened for risk factors by univariate and multivariate logistic regression.A prediction model for PTR was constructed using receiver operating characteristic(ROC)curve,calibration curve and decision curve(DCA)to assess the differentiation,calibration and clinical value of the model,respectively.Results A total of 334 hematological patients were included,including 168 males and 176 females,with a PTR incidence of 40.4%.Univariate and multivariate logistic regression analysis showed that platelet transfusion vol-ume,erythrocyte transfusion volume,and neutrophil ratio were risk factors for PTR(P<0.05).A prediction model for PTR in hematological patients was established based on these risk factors.The area under the model's curve was 0.8377(95%CI:0.723-0.772),the sensitivity was 58.52%,and the specificity was 89.95%.The calibration curve showed that the S∶P was 0.964,the maximum absolute difference Emax was 0.032,and the average absolute difference Eavg was 0.009.The DCA a-nalysis showed that the model had clinical application value when the risk threshold ranged from 0.2 to 0.9.Conclusion The PTR prediction model based on platelet transfusion volume,erythrocyte transfusion volume and neutrophil ratio can pro-vide a basis for effective platelet transfusion in hematological patients.关键词
血小板输注不良/危险因素/预测模型Key words
platelet transfusion refractoriness(PTR)/risk factors/prediction model分类
医药卫生引用本文复制引用
岳姝含,黄秀兰,曾彦,雷乔,何梦珍,卢黎琦,游时松,张静薇..血液病患者血小板输注无效的预测模型构建[J].中国输血杂志,2024,37(8):890-895,939,7.基金项目
四川省自然科学基金面上项目(23NSFSC1745) （23NSFSC1745）
