中国输血杂志2024，Vol.37Issue(8)：896-901,6.DOI:10.13303/j.cjbt.issn.1004-549x.2024.08.009
超溶血综合征患者的诊断分析和临床治疗策略
Diagnostic analysis and clinical treatment strategies for patients with hyperhemolytic syndrome:a case report
摘要
Abstract
Objective To analyze a case of hyperhemolytic syndrome(HHS)and explore the laboratory diagnostic method and clinical treatment strategy.Methods Serological tests such as blood typing,direct antiglobulin test(DAT),an-ti-screening and antibody identification were performed,The complete blood count(CBC),as well as hemolysis indicators such as lactate dehydrogenase(LDH)and bilirubin were tested,and the changes and progression of hemolysis were moni-tored.By using genotyping methods to test 32 common rare blood type antigens in clinical practice,the accuracy of antibody identification results was supported.Results The patient had anti-E antibodies and autoantibodies in her serum.After blood transfusion,LDH and bilirubin increased significantly,but hemoglobin dropped sharply,far lower than before transfusion,presenting with unique manifestations such as hemoglobinuria.The patient made a full recovery after treatment with high-dose intravenous immunoglobulin and corticosteroids.Conclusion HHS is a rare and potentially fatal diseases,which is mainly manifested by hemolysis and severe anemia,and the hemoglobin level after blood transfusion is often lower than that before blood transfusion.This patient had typical clinical manifestations of post-transfusion hyperhemolytic reaction.After timely and correct treatment,the patient recovered completely and was discharged,accumulating valuable clinical experience for the diagnosis and treatment of such disease.关键词
超溶血综合征/溶血性贫血/自身抗体/血红蛋白尿Key words
hyperhemolytic syndrome(HHS)/hemolytic anemia/autoantibodies/hemoglobinuria分类
医药卫生引用本文复制引用
敖正才,朱文磊,肖明菊..超溶血综合征患者的诊断分析和临床治疗策略[J].中国输血杂志,2024,37(8):896-901,6.基金项目
2022年度成都中医药大学"杏林学者"学科人才科研提升计划(YYZX202203) （YYZX202203）
