维持性血液透析患者血清镁水平与死亡因素分析OA北大核心CSTPCD

Objective To investigate the effect of serum magnesium level on all-causeand cardiovascular and cerebrovascular mortality in maintenance hemodialysis(MHD)patients.Methods A total of 114 MHD patients meeting the inclusion and exclusion criteria were included as the research subjects,who were on MHD in the Outpatient Department of the General Hospital of Ningxia Medical University in June 2017.Clinical data and biochemical results were collected before dialysis,and the MHD patients were divided into three groups according to the tertiles of serum magnesium level.All patients were followed up until endpoint event or November 30,2022.Compare the clinical data of the three groups,Kaplan-meier survival analysis was performed and Cox risk regression model was used to analyze the factors influencing the mortality in MHD patients.Results In the 114 MHD patients,40 patients were in the Low-level group(Mg≤ 1.10 mmol/L),36 patients were in the Mid-level group(Mg 1.10～1.24 mmol/L),and 38 patients were in the High-level group(Mg≥1.24 mmol/L).There were significant differences in total protein,serum albumin and prevalence of diabetes among the three groups(P＜0.05).Multiple linear regression analysisshowed that serum magnesium hadan effect on serum albumin(β=0.010,P=0.034)and iPTH(β=0.001,P=0.002).Multivariate Cox regression analysis showed that the risk of all-causedeath in the Low-level group was 2.947 times higher than that inthe High-level group(P＜0.05),while the risk of cardiovascular and cerebrovascular death was 3.774 times higher.Kaplan-Meier survival analysis showed that there was a significant difference in survival rate among the three groups(x2=6.607,P=0.048),and the Low-level group had the highest all-cause mortality rate.Conclusion The decreasing in serum magnesium level is associated with all-cause,cardiovascular and cerebrovascular mortalityin MHD patients.With serum magnesium≤ 1.10 mmol/L,all-cause mortality and cardiovascular and cerebrovascular mortality are higher.