中国实用外科杂志2024，Vol.44Issue(7)：756-761,6.DOI:10.19538/j.cjps.issn1005-2208.2024.07.08
直肠癌新辅助免疫治疗不良反应研究进展
Advances in adverse events of neoadjuvant immunotherapy in rectal cancer
摘要
Abstract
Neoadjuvant immunotherapy for rectal cancer has become a research hotspot in recent years,and early clinical trials exhibit encouraging outcomes.Generally speaking,immune checkpoint inhibitors(ICIs)have shown higher safety and cause no increase in surgery-related complications,but a small proportion of patients may experience severe immune-related adverse events(irAEs)that can impact subsequent treatments or threaten life.Currently,clinical research on neoadjuvant immunotherapy is in its early stages,with small sample sizes and relatively young,generally healthy patients being included.The safety for special populations,such as the elderly or those with autoimmune diseases,remains to be confirmed.Research on the mechanisms,prediction,diagnosis,and management remains insufficient.ICI treatment typically combines with chemoradiotherapy,complicating irAE diagnosis and management.Therefore,guidelines for managing adverse reactions to neoadjuvant immunotherapy should be established.Neoadjuvant immunotherapy regimens include multifarious methods such as concurrent immunotherapy with chemoradiotherapy,sequential chemoradiotherapy followed by immunotherapy,and total neoadjuvant therapy(TNT)combined with immunotherapy.The number of immunotherapy sessions also varies.Larger-scale clinical studies are required to develop personalized treatment plans that maximize efficacy and minimize adverse reactions.关键词
直肠癌/免疫治疗/免疫检查点抑制剂/新辅助治疗/免疫相关不良反应Key words
rectal cancer/immunotherapy/immune check-point inhibitors/neoadjuvant therapy/immune-related adverse events分类
医药卫生引用本文复制引用
林国乐,王晨童..直肠癌新辅助免疫治疗不良反应研究进展[J].中国实用外科杂志,2024,44(7):756-761,6.基金项目
中央高水平医院临床科研专项(No.2022-PUMCH-C-005) （No.2022-PUMCH-C-005）
中国医学科学院医学与健康科技创新工程项目(No.2022-I2M-C&T-B-032) （No.2022-I2M-C&T-B-032）
