中国实用外科杂志2024，Vol.44Issue(7)：774-780,7.DOI:10.19538/j.cjps.issn1005-2208.2024.07.12
结直肠癌靶向治疗的耐药机制及潜在解决方案
Drug resistance mechanisms of targeted therapy of colorectal cancer and potential solutions
摘要
Abstract
The drug resistance of colorectal cancer is closely related to individual differences and the heterogeneity of tumor cells,among which the different mutation loads of drug resistance-related genes largely determine the therapeutic effect of tumor-targeted drugs.Epidermal growth factor receptor(EGFR)and vascular endothelial growth factor receptor(VEGFR)are currently the clearest targets with the most diverse related drugs in the targeted therapy of colorectal cancer.In the past few decades,the adjuvant treatment methods for colorectal cancer have been constantly evolving.However,in clinical practice,there are difficulties in developing new drugs for many targets with well-proven drug resistance,and a wider range of molecular markers are needed to evaluate the adaptability and efficacy of targeted therapy.The highly sensitive genome sequencing methods and continuously improving molecular detection methods have brought great convenience to explore the drug resistance mechanism of colorectal cancer and evaluate the expression of personalized molecules.By continuously deepening the understanding of the drug resistance mechanism of colorectal cancer,it is expected to explore more targeted treatment loci for colorectal cancer and provide personalized adjunctive treatment plans for patients by individually evaluating the molecular expression characteristics of different patients,improving the prognosis of advanced colorectal cancer patients.关键词
结直肠癌/靶向治疗/耐药/表皮生长因子受体/血管内皮生长因子受体Key words
colorectal cancer/targeted therapy/drug resis-tance/epidermal growth factor receptor/vascular endothelial growth factor receptor分类
医药卫生引用本文复制引用
张宏,卜嘉文..结直肠癌靶向治疗的耐药机制及潜在解决方案[J].中国实用外科杂志,2024,44(7):774-780,7.基金项目
辽宁省民生科技计划项目(No.2021JH2/10300053) （No.2021JH2/10300053）
辽宁省教育厅基本科研项目(No.JYTMS20230101) （No.JYTMS20230101）
