摘要
Abstract
Objective To explore the risk factors and preventive strategies of cognitive dysfunction in patients after coronary artery bypass grafting(CABG).Methods The clinical data of 151 patients with coronary heart disease who received CABG in Pingdingshan Second People's Hospital from March 2021 to June 2023 were retrospectively collected and analyzed.According to the Mini Mental State Assessment Scale(MMSE),they were divided into 46 in the cognitive impairment groups and 105 in the non-cognitive impairment groups.The clinical data of the two groups(n=46)and the risk factors of cognitive dysfunction in patients after CABG were analyzed by multivariate Logistic regression analysis,and the corresponding receiver operating characteristic curve(ROC)prediction model was constructed.Results Compared with the non-cognitive impairment group,the proportion,age,Gensini score and serum uric acid(UA)level of patients with hypertension and diabetes were relatively higher,and the operation time and ICU time were longer(P<0.05).The results of multivariate Logistic regression analysis showed that the older age,hypertension,diabetes,higher Gensini score,longer operation time,longer ICU time and higher serum UA level were independent risk factors for cognitive dysfunction in patients after CABG(OR=1.514,1.445,1.484,1.514,1.527,1.418,1.594,P<0.05).The ROC curve analysis showed that the area under curve was 0.818,the 95%CI was 0.744-0.878,the sensitivity was 92.68%,and the specificity was 61.62%.Conclusion Risk factors affecting cognitive dysfunction in patients after CABG include older age,hypertension,diabetes,higher score of Gensini,longer operation time,longer ICU time and higher level of serum UA.It provides a new idea for early warning of cognitive dysfunction after CABG,so that clinical intervention can be carried out accordingly,thus reducing the occurrence of postoperative cognitive dysfunction.关键词
冠状动脉旁路移植术/认知功能障碍/风险因素/预防策略Key words
Coronary artery bypass grafting/Cognitive dysfunction/Risk factors/Preventive strategy
