中国畜牧杂志2024，Vol.60Issue(8)：1-6,6.DOI:10.19556/j.0258-7033.20240614-11
超级增强子在骨骼肌发育过程中的研究进展
Research Progress of Super Enhancers in Skeletal Muscle Development
摘要
Abstract
Super Enhancers(SEs)are a type of cis acting element in the genome with a length between 8-20 kb and strong transcriptional activation properties.SEs are enriched with high-density key transcription factors(Master Transcription Factors),transcriptional co activating factors such as Bromodomain Containing Protein 4(BRD4),Mediator Cohesin,and histone modification markers such as H3K27ac and H3Kme1.SEs play a crucial role in regulating muscle cell differentiation,skeletal muscle cell growth and development,and maintaining muscle cell identity and fate.Therefore,this article summarizes the role and regulatory mechanism of SEs in skeletal muscle development,providing theoretical reference for further understanding the mechanism of SEs and other cis regulatory elements in regulating skeletal muscle development and their application in the treatment and application of muscle diseases.关键词
超级增强子/超级增强子RNA/骨骼肌发育/转录因子/肌肉疾病Key words
Super enhancer/Super enhancer RNA/Skeletal muscle development/Transcription factors/Muscle diseases分类
农业科技引用本文复制引用
黄慧君,谭宝华,肖丽窈,杨玉铭,洪林君,黄思秀,蔡更元,顾婷..超级增强子在骨骼肌发育过程中的研究进展[J].中国畜牧杂志,2024,60(8):1-6,6.基金项目
广东省重点领域研发计划(2022B0202090002) （2022B0202090002）
