中国畜牧杂志2024，Vol.60Issue(8)：13-20,8.DOI:10.19556/j.0258-7033.20240529-07
蛋白翻译后修饰在PRRSV感染中的作用机制
The Mechanism of Protein Post-translational Modifications in PRRSV Infection
摘要
Abstract
Porcine reproductive and respiratory syndrome virus(PRRSV)is a pathogen that seriously threatens the global pig industry,and its pathogenic mechanism has not been fully resolved.Post-translational modification of proteins is crucial to protein function,and can fine-regulate protein activity,stability and localization,thus affecting biological processes such as cell growth,differentiation and apoptosis.It triggers a series of complex biological processes during PRRSV infection.Among them,protein post-translational modification plays a crucial role in virus infection of the host cells,which can affect the host's recognition of the virus,and participate in the regulation of virus replication,proliferation and disease occurrence.This paper reviews the research progress on the mechanism of protein post-translational modifications such as phosphorylation,ubiquitination,glycosylation,palmitoylation,acetylation and lactation in PRRSV infection.It will provide a new idea for the study of pathogenesis of PRRSV,and provide a theoretical basis for the research and development of anti-PRRSV drugs.关键词
蛋白翻译后修饰/PRRSV/病毒感染/猪Key words
Post-translational modifications/PRRSV/Viral infection/Pig分类
畜牧业引用本文复制引用
刘后春,周傲,陈洪波,彭先文,梅书棋,吴俊静..蛋白翻译后修饰在PRRSV感染中的作用机制[J].中国畜牧杂志,2024,60(8):13-20,8.基金项目
国家重点研发计划项目(2021YFD1301101) （2021YFD1301101）
国家生猪产业技术体系项目(CARS-35) （CARS-35）
湖北省农业科技创新中心创新团队项目(2021-620-000-001-018) （2021-620-000-001-018）
