重组贻贝粘蛋白敷料对CO2点阵激光术后创面修复的作用OA

Objective Evaluate the effectiveness and safety of recombinant mussel adhesive protein dressing at different concentrations for covering and caring for post-CO2 fractional laser wounds.Methods The Shenzhen People's Hospital recruited 36 postoperative patients from November 2023 to April 2024,undergoing carbon dioxide fractional laser treatment and randomly divided them into three groups,with 12 cases in each group.The control group received intervention with recombinant collagen dressing,while the observation groups were treated with recombinant abalone adhesive protein dressing at different concentrations(Group A:0.2 g/L,Group B:0.5 g/L)after CO2 fractional laser treatment.Subsequently,a 28-day follow-up was conducted with observations at different time points,including scab shedding,acute inflammation scores,patient satisfaction scores,skin barrier and VISIA indicators,and collecting adverse events.Results The main effectiveness evaluation indicator,the healing time of post-treatment wounds,showed no statistically significant difference between the two observation groups and the control group.Secondary evaluation indicators included acute inflammation scores,patient satisfaction scores,and skin barrier indicators.Among these,on the third day after treatment,desquamation value in Group A was(0.17±0.08),significantly lower than the control group's(0.35±0.18),showing a statistical difference(P<0.05);Group B showed a significant increase in skin tightness on the 7tth day compared to the control group(P<0.05).Regarding patient satisfaction scores,both Group A and B scored significantly higher than the control group on multiple indicators,including"improvement of sensitivity discomfort after the procedure,""skin becoming more hydrated and moisturized,"and"overall improvement of skin condition"(P<0.05).In skin barrier indicators,Group B had significantly lower TEWL scores than the control group on the 14tth day(P<0.05);in VISIA detection indicators,pigment area in Group A on the 14tth day was significantly lower than the control group(P<0.05).In terms of safety,no adverse reactions were observed in all participants.Conclusions Recombinant mussel adhesive protein dressing is not inferior to currently available recombinant collagen dressing in terms of safety and efficacy for post-laser repair.It outperforms collagen dressing in certain indicators such as desquamation,trans-epidermal water loss,pigment area,and subjective perception by participants.