中国药物经济学2024，Vol.19Issue(7)：48-52,5.DOI:10.12010/j.issn.1673-5846.2024.07.009
急诊经皮冠状动脉介入治疗术中硝普钠与替罗非班联合重组人尿激酶原冠状动脉内注射治疗高血栓负荷ST段抬高型心肌梗死患者的效果
Effect of Sodium Nitroprusside,Tirofiban and Rh-proUK by Intracoronary Injection in STEMI Patient with High Thrombus Load During PCI
摘要
Abstract
Objective To explore the effect of sodium nitroprusside,tirofiban and rh-proUK by intracoronary injection in ST-elevation myocardial infarction(STEMI)patient with high thrombus load during percutaneous coronary intervention(PCI).Methods A total of 86 STEMI patients with high thrombotic load who underwent PCI in the cardiovascular Department of Hechi People's Hospital from November 2022 to November 2023 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 43 cases in each group.The control group was successively injected with sodium nitroprusside and tirofiban in the coronary artery,while the observation group was successively injected with recombinant human urokinase,sodium nitroprusside and tirofiban in the coronary artery.Creatine kinase isoenzyme(CK-MB),troponin I(cTnI),TIMI blood flow grading,TIMI myocardial perfusion grading(TMPG),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),N-terminal brain natriuretic peptide precursor(NT-proBNP),and major adverse cardiovascular events(MACE)and the occurrence of bleeding events were compared between two groups.Results After operation,CK-MB and cTnI in observation group were higher than those in control group(P＜0.05).Immediately after operation,TIMI blood flow grading and TMPG grading in observation group were improved compared with control group(P＜0.05).Three months after surgery,there was no significant difference in LVEDD and LVEF between the two groups(P＞0.05),and NT-proBNP in the observation group was lower than that in the control group(P＜0.05).The incidence of MACE in the observation group was lower than that in the control group(P＜0.05).There was no significant difference in the incidence of bleeding events between the two groups(P＞0.05).Conclusion Recombinant human urokinase,sodium nitroprusside and tirofiban combined with intra-coronary injection during emergency PCI can improve myocardial perfusion and cardiac function and reduce the risk of MACE in STEMI patients with high thrombotic load.关键词
经皮冠状动脉介入治疗/高血栓负荷/重组人尿激酶原/ST段抬高型心肌梗死Key words
Percutaneous coronary intervention/High thrombus load/Rh-proUK/ST-elevation myocardial infarction分类
医药卫生引用本文复制引用
贝晓娜,莫昌干,韩辉,韦利元,夏景敏,韦颖..急诊经皮冠状动脉介入治疗术中硝普钠与替罗非班联合重组人尿激酶原冠状动脉内注射治疗高血栓负荷ST段抬高型心肌梗死患者的效果[J].中国药物经济学,2024,19(7):48-52,5.基金项目
右江民族医学院2021年度校级科研课题(yy2021sk111) （yy2021sk111）
