摘要
Abstract
Objective To explore the effect of Banxia Baizhu Tianma Tang combined with Taohong Siwu Tang on the circadian rhythm of blood pressure in patients with primary hypertension with phlegm stasis obstruction type.Methods A total of 86 patients diagnosed with essential hypertension and consistent with phlegm stasis block type in Baoji Third Hospital from January 2021 to January 2022 were selected as the study objects,and were divided into observation group and control group by random number table method,with 43 cases in each group,of which 1 case fell out due to serious adverse reactions in the observation group.The control group was treated with amlodipine besylate tablets and valsartan amlodipine tablets,and the observation group was treated with Banxia Baizhu Tianma Decoction and Taohong Siwu decoction on the basis of the control group.Blood pressure circadian rhythm,blood pressure variability(BPV)[24 h mean systolic blood pressure variability(24 h SBPV),24 h mean diastolic blood pressure variability(24 h SBPV)],morning peak blood pressure(MBPS),morning peak phenomenon+incidence,TCM syndrome score before and after treatment,TCM syndrome efficacy and occurrence of adverse reactions were compared between the two groups.Results After treatment,the circadian rhythm of systolic blood pressure and diastolic blood pressure were significantly improved in both groups,and the observation group was significantly better than the control group,the difference was statistically significant(P＜0.05).After treatment,24 h SBPV and 24 h DBPV in both groups were lower than before treatment(P＜0.05),and observation group was lower than control group(P＜0.05).After treatment,the incidence of MBPS and morning peak phenomenon+in the two groups was lower than before treatment(P＜0.05),and the incidence of MBPS and morning peak phenomenon+in the observation group was lower than that in the control group(P＜0.05).After treatment,the TCM syndrome score of both groups was significantly decreased(P＜0.05),and the observation group was significantly lower than the control group(P＜0.05).The curative effect of TCM syndrome in the observation group was significantly higher than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Banxia Baizhu Tianma Decoction combined with Taohong Siwu Decoction can effectively improve the circadian rhythm of blood pressure in patients with essential hypertension with phlegm stasis block,reduce BPV,control MBPS,improve TCM syndrome score,and improve the efficacy of TCM syndrome,with less adverse reactions and high safety.关键词
半夏白术天麻汤/桃红四物汤/原发性高血压/痰瘀阻滞型/血压昼夜节律/血压变异性/晨峰血压Key words
Banxia Baizhu Tianma Tang/Taohong Siwu Tang/Primary hypertension/Phlegm stasis obstruction type/Blood pressure circadian rhythm/Blood pressure variability/Morning peak blood pressure分类
医药卫生
