中国医院用药评价与分析2024，Vol.24Issue(7)：783-788,6.DOI:10.14009/j.issn.1672-2124.2024.07.004
基于数据挖掘和网络药理学探讨中药治疗慢性萎缩性胃炎伴肠上皮化生的用药规律及机制研究
Medication Laws and Mechanism of Traditional Chinese Medicine in the Treatment of Chronic Atrophic Gastritis Complicated with Intestinal Metaplasia Based on Network Pharmacology and Data Mining
摘要
Abstract
OBJECTIVE:To explore medication laws of traditional Chinese medicine in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia,and to analyze the potential mechanism of common drug pairs.METHODS:CNKI,Wanfang and VIP databases were retrieved(from database establishment to Jun.30th,2022).Excel,SPSS Modeler 18.1 and SPSS Statistics 26 were used for frequency statistics,association rule analysis and cluster analysis of the included traditional Chinese medicine.Protein-protein interaction,Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,GeneCards,STRING,Cytoscape and other tools to reveal the potential mechanisms.RESULTS:A total of 100 prescriptions were screened out,with 187 traditional Chinese medicines.The medicinal properties were mainly warm,calm and cold.The medicinal tastes were mainly bitter and sweet.The main meridians were spleen and stomach.There were 21 kinds of traditional Chinese medicine used more than 20 times.Atractylodes macrocephala koidz-Hedyotis diffusae herba was the most supported drug combination.The key components of Atractylodes macrocephala koidz-Hedyotis diffusae herba in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia were quercetin,β-sitosterol and stigmasterol.The core targets were tumor protein p53,protein kinase B1 and transcription factor AP-1.The main pathways of action were tumor-associated pathways,hepatitis B virus and advanced glycosylation end(AGE)product-AGE receptor signaling pathways.Molecular docking results showed strong binding activity of 3 key components to 3 core targets.CONCLUSIONS:Traditional Chinese medicine in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia mainly based on strengthening the spleen,regulating the Qi,clearing heat and promoting blood circulation.Atractylodes macrocephala koidz-Hedyotis diffusae herba exerts the therapeutic effects on chronic atrophic gastritis complicated with intestinal metaplasia from multiple components,multiple targets and multiple pathways,laying a theoretical foundation for further mechanism research.关键词
中药/慢性萎缩性胃炎/肠上皮化生/用药规律/作用机制Key words
Traditional Chinese medicine/Chronic atrophic gastritis/Intestinal metaplasia/Medication laws/Mechanism分类
医药卫生引用本文复制引用
李萌,田志华,陈丁铭,陈敬予,王少丽,刘震..基于数据挖掘和网络药理学探讨中药治疗慢性萎缩性胃炎伴肠上皮化生的用药规律及机制研究[J].中国医院用药评价与分析,2024,24(7):783-788,6.基金项目
国家自然科学基金资助项目(No.82174352) （No.82174352）
首都卫生发展科研专项资助项目(No.首发2020-2-4152) （No.首发2020-2-4152）
中央高水平中医医院临床科研业务费资助项目(No.HLCMHPP2023085) （No.HLCMHPP2023085）
