中国医院用药评价与分析2024，Vol.24Issue(7)：793-796,4.DOI:10.14009/j.issn.1672-2124.2024.07.006
复方苦参注射液联合DCF化疗方案对胃癌术后患者并发症及Th17/Treg平衡的影响
Effects of Compound Kushen Injection Combined with DCF Chemotherapy Regimen on Postoperative Complications and Th17/Treg Balance in Patients with Gastric Cancer
摘要
Abstract
OBJECTIVE:To probe into the effects of compound Kushen injection combined with DCF chemotherapy regimen on postoperative complications and Th17/Treg balance in patients with gastric cancer.METHODS:Totally 96 patients with gastric cancer who underwent surgical treatment in the hospital from Oct.2022 to Aug.2023 were extracted to be divided into the compound Kushen injection group and control group according to different treatment regimens,with 48 cases in each group.Both groups received radical surgery.The control group was treated with DCF chemotherapy regimen(docetaxel+cisplatin+5-fluorouracil),while the compound Kushen injection group received compound Kushen injection on the basis of the control group.The incidence of postoperative complications and changes in Th17,Treg,and Th17/Treg indicators were compared between two groups.RESULTS:After treatment,the incidence of complications in compound Kushen injection group was 10.42%(5/48),lower than 35.42%(17/48)in control group,the difference was statistically significant(P<0.05).After treatment,Th17 and Th17/Treg indicators in both groups were higher than those before treatment,and the compound Kushen injection group was significantly higher than the control group,the differences were statistically significant(P<0.05).After treatment,Treg indicators in both groups were lower than those before treatment,and the compound Kushen injection group was significantly lower than the control group,with statistically significant difference(P<0.05).CONCLUSIONS:Compound Kushen injection can regulate the imbalance of T cell subsets in patients with gastric cancer after surgery,improve immune function,reduce the incidence of postoperative complications,and is more conducive to the prognosis of patients.关键词
复方苦参注射液/DCF化疗/胃癌/并发症/Th17/Treg平衡Key words
Compound Kushen injection/DCF chemotherapy/Gastric cancer/Complications/Th17/Treg balance分类
医药卫生引用本文复制引用
张浩,刘岗,蒋海锋,张熹玮..复方苦参注射液联合DCF化疗方案对胃癌术后患者并发症及Th17/Treg平衡的影响[J].中国医院用药评价与分析,2024,24(7):793-796,4.基金项目
上海市中医药三年行动计划(2021-2023)项目[No.ZY(2021-2023)-0201-02] （2021-2023）
