瑞舒伐他汀联合鹿瓜多肽辅助LCP内固定治疗对老年肱骨近端骨折患者骨代谢、再骨折的影响OACSTPCD

OBJECTIVE:To probe into the efficacy of rosuvastatin combined with Lugua polypeptide assisted locking compression plate(LCP)internal fixation in the treatment of bone metabolism and refracture in elderly patients with proximal humerus fracture.METHODS:Totally 108 elderly patients with proximal humerus fracture admitted into Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from Jan.to Aug.2022 were extracted to be divided into the control group and the observation group via the random number table method,with 54 cases in each group.After LCP internal fixation,the control group was given Lugua polypeptide,while the observation group received rosuvastatin combined with rosuvastatin.The clinical efficacy,operative related indicators,complications,bone mineral density(BMD),bone metabolism indicators such as tartrate acid phosphatase-5b(TRACP-5b),type Ⅰ collagen cross-linked amino terminal peptide(NTXⅠ)and osteocalcin(BGP),fracture repair cytokines such as bone morphogenetic protein-2(BMP-2),vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGF-β1)before and after treatment were observed in two groups.RESULTS:The excellent and good rate of observation group was 92.59%(50/54),higher than 74.07%(40/54)of control group,with statistically significant difference(P<0.05).Weight bearing and fracture healing time of observation group were shorter than those of control group,with statistically significant difference(P<0.05).After treatment,the L3 and L4 BMD of lumbar spine in observation group were higher than those in control group,the levels of TRACP-5b and NTXⅠ were lower than those in control group,the levels of BGP were higher than those in control group,the levels of VEGF and BMP-2 were higher than those in control group,the levels of TGF-β1 were lower than those in control group,with statistically significant differences(P<0.05).The complication rate of the observation group was 5.56%(3/54),compared with 16.67%(9/54)in the control group,the difference was not statistically significant(P>0.05).CONCLUSIONS:Rosuvastatin combined with Lugua polypeptide can accelerate early recovery after LCP internal fixation and promote fracture healing in elderly patients with proximal humerus fracture,which may be related to rosuvastatin can improve bone mineral density and bone metabolism,and regulate repair cytokines.