中成药2024，Vol.46Issue(8)：2587-2591,5.DOI:10.3969/j.issn.1001-1528.2024.08.014
乌蔹莓灌肠对远端溃疡性结肠炎患者的临床疗效
Clinical effects of enema of Cayratia japonica on patients with distal ulcerative colitis
摘要
Abstract
AIM To explore the clinical effects of enema of Cayratia japonica(Thunb.)Gagnep.on patients with distal ulcerative colitis.METHODS Sixty patients were randomly assigned into control group(30 cases)for 8-week intervention of Mesalazin Enteric-coated Tablets,and observation group(30 cases)for 8-week intervention of both enema of C.japonica and Mesalazin Enteric-coated Tablets.The changes in clinical effects,life quality scores,DAI score,Mayo activity index,intestinal mucosal barrier function indices(DAO,ET,D-lactic acid),intestinal flora(Bifidobacterium,Lactobacillus,Escherichia coli,Enterococcus),inflammatory factors(IL-10,IL-6,TNF-α)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the observation group displayed increased life quality scores,IL-10(P＜0.05),decreased DAI score,Mayo activity index,intestinal mucosal barrier function indices,IL-6,TNF-α(P＜0.05),enhanced Bifidobacterium,Lactobacillus(P＜0.05),and reduced Escherichia coli,Enterococcus(P＜0.05),which were more obvious than those in the control group(except for Enterococcus)(P＜0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with distal ulcerative colitis,enema of C.japonica can safely and effectively improve DAI score and Mayo activity index,which may contribute to the regulation of bacterial homeostasis,repairment of intestinal mucosal barrier and inhibition of inflammatory factor release.关键词
乌蔹莓/灌肠/美沙拉嗪肠溶片/远端溃疡性结肠炎Key words
Cayratia japonica(Thunb.)Gagnep./enema/Mesalazin Enteric-coated Tablets/distal ulcerative colitis分类
医药卫生引用本文复制引用
张荣,李芳,黄华,丁旭枫,季利江..乌蔹莓灌肠对远端溃疡性结肠炎患者的临床疗效[J].中成药,2024,46(8):2587-2591,5.基金项目
江苏省中医药管理局面上项目(MS2021058,MS2023099) （MS2021058,MS2023099）
常熟市科技局立项项目(CS202030) （CS202030）
常熟市卫健委重点项目(csws202119) （csws202119）
常熟市卫生局指导项目(2019) （2019）
南京中医药大学自然科学基金项目(XZR2020062) （XZR2020062）
