中成药2024，Vol.46Issue(8)：2596-2600,5.DOI:10.3969/j.issn.1001-1528.2024.08.016
虎杖对湿热证2型糖尿病患者的临床疗效
Clinical effects of Polygonum cuspidatum on patients with type 2 diabetes mellitus of Dampness-Heat Pattern
摘要
Abstract
AIM To explore the clinical effects of Polygonum cuspidatum Sieb.et Zucc.on patients with type 2 diabetes mellitus of Dampness-Heat Pattern.METHODS One hundred and forty patients were randomly assigned into control group(70 cases)for 8-week intervention of conventional treatment,and observation group(70 cases)for 8-week intervention of both P.cuspidatum granules and conventional treatment.The changes in body weight,BMI,blood glucose indices(FBG,2 h PG,HbA1C,GA),blood lipid indices(TC,TG,HDL-C,LDL-C,ApoA-I,ApoB,ApoA,ApoE,sdLDL-C),liver function indices(ALT,AST),fatty liver progression,TyG,HSI,TCM syndrome score and effects were detected.RESULTS The observation group demonstrated higher total effective rates of TCM syndromes than the control group(P＜0.01),along with slighter fatty liver progression(P＜0.01).After the treatment,the observation group displayed decreased body weight,BMI,FBG,GA,TG,ApoE,TyG,HSI,ALT and TCM syndrome score(P＜0.05,P＜0.01),and 2 h PG,TyG,HSI,ALT,TCM syndrome score were lower than those in the control group(P＜0.05,P＜0.01).CONCLUSION For the patients with type 2 diabetes mellitus of Dampness-Heat Pattern,P.cuspidatum can improve glucose and lipid metabolism disorders,which is worthy of clinical popularization and application.关键词
虎杖/常规治疗/2型糖尿病/湿热证Key words
Polygonum cuspidatum Sieb.et Zucc./conventional treatment/type 2 diabetes mellitus/Dampness-Heat Pattern分类
医药卫生引用本文复制引用
徐媛颖,孔稳稳,尹宏萍,张会会,蔡兴华,徐碧林,沙雯君,雷涛..虎杖对湿热证2型糖尿病患者的临床疗效[J].中成药,2024,46(8):2596-2600,5.基金项目
国家自然科学基金面上基金资助项目(81774083) （81774083）
上海市普陀区卫生健康系统科技创新项目(ptkwws202003) （ptkwws202003）
上海市普陀区临床特色专科(2020tszk01) （2020tszk01）
上海市医学重点专科(ZK2019B16) （ZK2019B16）
上海市卫生健康委员会科研课题(20204Y0154) （20204Y0154）
上海市卫健委课题(202240309) （202240309）
