盐酸右美托咪定两种给药方式在腹腔镜下卵巢囊肿剥除术中的应用效果比较研究OA

Objective:To compare the efficacy of two modes of administration of dexmedetomidine hydrochloride in laparoscopic ovarian cyst removal.Method:A total of 168 patients who underwent laparoscopic ovarian cyst removal surgery in Changle District Maternal and Child Health Hospital of Fuzhou City from March 2021 to September 2023 were selected as the study subjects,and they were divided into the control group,the intravenous drug administration group,and the transnasal drug administration group by using computer software,with 56 cases in each group.Patients in the control group were injected with saline intravenously before induction of anesthesia,patients in the intravenous administration group were given dexmedetomidine hydrochloride pumped intravenously before induction of anesthesia,and patients in the transnasal administration group were given dexmedetomidine hydrochloride drops in the nose before induction of anesthesia.The hemodynamic indexes,the quality of postoperative recovery and the occurrence of adverse reactions were compared among the three groups of patients 10 min before the induction of anesthesia(T0),10 min after the induction of anesthesia(T1),30 min after the induction of anesthesia(T2),and at the time of the incision suture(T3).Result:Mean arterial pressure(MAP)and heart rate(HR)at T1,T2 and T3 of patients in the intravenous administration group and the transnasal administration group were compared with those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the comparison of MAP and HR at each time point between patients in the intravenous drug administration group and the transnasal drug administration group(P>0.05).The postoperative awakening time of patients in the intravenous drug administration group and the transnasal drug administration group was shorter than that of the control group,and the 15-item Quality of Recovery Rating Scale(QoR-15)score was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the comparison of the above indexes between patients in the intravenous drug administration group and the transnasal drug administration group(P>0.05).The incidence of hypotension and bradycardia in patients in the transnasal drug delivery group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Both transnasal and intravenous administration of dexmedetomidine hydrochloride can improve hemodynamics and the quality of postoperative recovery in patients undergoing laparoscopic ovarian cystectomy,but transnasal administration can reduce the incidence of adverse effects.