摘要
Abstract
Objective:To explore the application effect of neuromuscular electrical stimulation in patients with depression after cerebral infarction.Method:A retrospective analysis was conducted on 100 patients with depression after cerebral infarction admitted to the Fuzhou First General Hospital from January 2021 to January 2023.According to different treatment methods,they were divided into a control group and an observation group,with 50 cases in each group.Both groups received routine treatment,the control group received routine antidepressant treatment,and the observation group received neuromuscular electrical stimulation treatment on the basis of the control group.The negative emotions and neurological function,neurotransmitters,neuronal damage markers before and 8 weeks after treatment,related indicators,and clinical efficacy between two groups were compared.Result:After 8 weeks of treatment,the scores of Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD)and National Institutes of Health stroke scale(NIHSS)were decreased in both groups,and the HAMA score,HAMD score and NHISS score in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After 8 weeks of treatment,the levels of 5-hydroxytryptamine(5-HT),norepinephrine(NE)and brain-derived neurotrophic factor(BDNF)in both groups were increased,and the levels of 5-HT,NE and BDNF in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After 8 weeks of treatment,the levels of glial fibrillary acidic protein(GFAP),intercellular adhesion molecule-1(ICAM-1)and β-actin(β-actin)in both groups were decreased,and the levels of GFAP,ICAM-1 and β-actin in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 8 weeks of treatment,heat shock protein 70(HSP70)increased,and the levels of peptide and S100 calc-binding protein β(S100-β)decreased in both groups,HSP70 levels in observation group was higher than that in control group,and the levels of peptide and S100-β in observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:The use of neuromuscular electrical stimulation in patients with depression after cerebral infarction can improve their negative emotions,increase HSP70 levels,and reduce levels of peptide and S100-βlevel,reduces nerve damage and promotes neural function recovery.关键词
神经肌肉电刺激/脑梗死后抑郁/神经功能/负面情绪Key words
Neuromuscular electrical stimulation/Depression after cerebral infarction/Neurological function/Negative mood
