重庆邮电大学学报（自然科学版）2024，Vol.36Issue(4)：697-706,10.DOI:10.3979/j.issn.1673-825X.202308070263
基于CODAE方法的脑膜炎疫苗相关不良反应图谱研究
Analytical investigation of adverse event profiles associated with the meningitis vaccines based on CODAE method
摘要
Abstract
This study aims to analyze and evaluate adverse event(AE)associated with five licensed meningitis vaccines(Menactra,Menveo,MenQuadfi,Trumenba and Bexsero)based on data from vaccine adverse event reporting system(VAERS).As of March 31,2023,the AE data associated Menactra,Menveo,MenQuadfi,Trumenba,and Bexsero were retrieved from VAERS database respectively.A total of 94 statistically significant adverse events were identified using the combinatorial ontology-based detection of vaccine adverse events method(CODAE),including 23 serious adverse events.By mapping out the ontology-based AE profiles,we showed that these significant AEs were clustered in the behavioral and neurological conditions.In addition,a statistical analysis with detailed information in death case reports was used to ascer-tain the major variables that might affect the occurrence of death AE.We found that variables such as the age of the vacci-nated person had a certain impact on the occurrence of death.However,the available data was relatively limited,and the relevant results needed further verification.The analysis and evaluation of adverse events indicated that the five currently marketed meningitis vaccines were relatively safe.The exact relationship between specific serious adverse events,vaccina-tion,and the condition of the vaccinated person deserved further in-depth research in future work.关键词
脑膜炎疫苗/不良反应(AE)/疫苗不良反应报告系统(VAERS)/不良反应本体Key words
meningitis vaccine/adverse event(AE)/vaccine adverse event reporting system(VAERS)/ontology of ad-verse events分类
信息技术与安全科学引用本文复制引用
张雪,苏俊,杨秋月,谢江安..基于CODAE方法的脑膜炎疫苗相关不良反应图谱研究[J].重庆邮电大学学报（自然科学版）,2024,36(4):697-706,10.基金项目
重庆市教育委员会科学技术研究项目(KJZD-K202000603) （KJZD-K202000603）
国家自然科学基金青年基金项目(61801067)The Science and Technology Research Program of Chongqing Municipal Education Commission(KJZD-K202000603) （61801067）
The National Natural Science Foundation of China(61801067) （61801067）
