高校化学工程学报2024，Vol.38Issue(4)：608-615,8.DOI:10.3969/j.issn.1003-9015.2024.04.009
基于羟乙基淀粉-姜黄素前药的SN38协同给药胶束构建与评价
Preparation and evaluation of SN38 synergetic therapeutic micelles based on hydroxyethyl starch-curcumin prodrug
摘要
Abstract
Synergetic chemotherapy can inhibit cancer cell proliferation via various metabolic pathways,which demonstrates superiorities in improving therapeutic efficacy and avoiding multidrug resistance.In this work,synergetic therapeutic micelles based on quaternary ammonium salt substituted hydroxyethyl starch-curcumin(QHES-S-CUR)conjugates were constructed to encapsulate 7-ethyl-10-hydroxycamptothecin(SN38).Stability of curcumin/SN38 mixture was assessed by molecular dynamics simulation.Then,synergetic therapeutic micelles loading with SN38 were prepared by nanoprecipitation.Effects of QHES-S-CUR/SN38 weight ratios on morphologies and size distributions of SN38@QHES-S-CUR were investigated in detail.At a weight ratio of 20:1,spherical nanoparticles with an average size of(258.76±28.76)nm could be obtained.In vitro drug release profiles indicated that curcumin and SN38 were released under the trigger of simulated tumor microenvironment.In addition,SN38@QHES-S-CUR exhibited more effective cytotoxicity to CT-26 cells than SN38 alone.This work expands the application of amphiphilic prodrugs to the delivery of hydrophobic chemotherapy drugs,which provides a new sight of synergetic chemotherapy.关键词
羟乙基淀粉/姜黄素/7-乙基-10-羟基喜树碱/前药/协同给药/胶束Key words
hydroxyethyl starch/curcumin/7-ethyl-10-hydroxycamptothecin/prodrug/synergetic therapy/micelle分类
化学化工引用本文复制引用
王子丹,韩银磊,彭虎红,关怡新,姚善泾..基于羟乙基淀粉-姜黄素前药的SN38协同给药胶束构建与评价[J].高校化学工程学报,2024,38(4):608-615,8.基金项目
国家自然科学基金(21878262). （21878262）
