哈尔滨医药2024，Vol.44Issue(4)：8-12,5.DOI:10.3969/j.issn.1001-8131.2024.04.003
血清Caspase-1、DKK-1、IL-2Rα水平与系统性红斑狼疮患者病情程度的相关性分析及临床价值
Correlation Analysis and Clinical Value of Serum Caspase-1,DKK-1,IL-2Rα Levels with Disease Degree of Patients with Systemic Lupus Erythematosus
摘要
Abstract
Objective To investigate the serum levels of Caspase-1(Caspase-1),Dickkopf-1(DKK-1)and interleukin-2 receptor α(IL-2Rα)in patients with systemic lupus erythematosus(SLE),and to analyze their correlation with the severity of the disease and their evaluation value in renal function impairment.Methods A total of 114 SLE patients were selected as the study group,and 38 healthy volunteers were selected as the control group.The levels of serum Caspase-1,DKK-1 and IL-2Rα were compared between the two groups and the study group with different disease course.The correlation between serum Caspase-1,DKK-1,IL-2Rα and clinical indicators(white blood cell count,hemoglobin,lymphocyte count,platelets,ery-throcyte sedimentation rate,serum creatinine,24 h urinary protein,anti-double DNA antibody(dsDNA),complement C3,com-plement C4)and disease degree was analyzed.According to the degree of renal impairment,the study group was divided into 58 cases with normal renal function,31 cases with mild abnormal renal function,and 25 cases with moderate and severe ab-normal renal function.The levels of serum Caspase-1,DKK-1 and IL-2Rα were compared,and the evaluation value of their on the degree of renal function impairment was analyzed.Results The levels of serum Caspase-1 in the study group were lower than those in the control group,and the levels of serum DKK-1 and IL-2Rα were higher than those in the control group(P<0.05).With the severity of disease and renal function,the serum Caspase-1 level was decreased,and the serum DKK-1 and IL-2Rα levels were increased(P<0.05).Serum Caspase-1 was positively correlated with white blood cell count,lymphocyte count,complement C3 and complement C4,but negatively correlated with erythrocyte sedimentation rate,anti-DSD-NA antibody and disease degree(P<0.05).Serum DKK-1 and IL-2Rα were negatively correlated with white blood cell count,lymphocyte count,complement C3 and complement C4,but positively correlated with erythrocyte sedimentation rate,anti-DSD-NA antibody and disease degree(P<0.05).The AUC of serum Caspase-1,DKK-1 and IL-2Rα combined in the assessment of renal lesion was higher than that of single index assessment(P<0.05).Conclusion Serum Caspase-1 levels are decreased and serum DKK-1 and IL-2Rα levels are increased in SLE patients,which are closely related to the severity of the disease.Combined detection of caspase-1 and IL-2rα levels has certain value in evaluating the degree of renal function impairment.关键词
系统性红斑狼疮/半胱氨酰天冬氨酸特异性蛋白酶-1/Dickkopf-1/白细胞介素-2受体α/肾功能Key words
Systemic lupus erythematosus/Cysteinylaspartic proteinase-1/Dickkopf-1/Interleukin-2 receptor α/Renal function分类
医药卫生引用本文复制引用
张静,胥艳,刘小静..血清Caspase-1、DKK-1、IL-2Rα水平与系统性红斑狼疮患者病情程度的相关性分析及临床价值[J].哈尔滨医药,2024,44(4):8-12,5.基金项目
河南省医学科技攻关联合共建项目(LHGJ20211043) （LHGJ20211043）
