哈尔滨医药2024，Vol.44Issue(4)：112-116,5.DOI:10.3969/j.issn.1001-8131.2024.04.034
正肝化症汤加减配合西药治疗对原发性肝癌患者肝功能及T淋巴细胞亚群的影响
Effects of the Addition and Subtraction of Zhenggan Huazheng Tang Together with Western Drug Therapy on Liver Function and T Lymphocyte Subpopulations in Patients with Primary Hepatocellular Carcinoma
摘要
Abstract
Objective To explore the application effect of the addition and subtraction of Zhenggan Huazheng Tang to-gether with western medicines(Capecitabine+Lenvatinib mesylate+Oxaliplatin)in the treatment of patients with Primary Liver Cancer(PLC).Methods 68 patients with PLC were retrospectively selected according to the matching principle for the study,they were divided into control group and observation group,with 34 cases in each group according to different treatment schemes.Among them,those who were treated with Capecitabine+Lenvartinib mesylate were included in the control group,and those who were treated with Zhenggan Huazheng Decoction plus Capecitabine+Lenvartinib mesylate were included in the ob-servation group.Objective remission rates were compared between the two groups,as well as the levels of liver function indi-cators[alkaline phosphatase(ALP),total bilirubin(TBIL)],T lymphocyte subsets(CD3+,CD4+/CD8+),and tumor markers[vimentin(VIM),alpha fetoprotein(AFP),Golgi protein 73(GP73)]before treatment,after 2 and 4 courses of treatment,and the occur-rence of toxic side effects was also compared between the two groups.Results The objective remission rate of the observa-tion group(64.71%)was higher than that of the control group(35.29%)(P<0.05);after 2 and 4 courses of treatment,the levels of ALP and TBIL in the observation group were lower than those in the control group(P<0.05);the levels of CD3+,CD4+/CD8+in the observation group were higher than those in the control group after 2 and 4 courses of treatment(P<0.05);the levels of VIM,AFP and GP73 in the observation group were lower than those in the control group after 2 and 4 courses of treatment(P<0.05);compared with the control group,there was no significant difference in the incidence of various toxic and side effects in the observation group(P>0.05).Conclusion Zhenggan Huazheng Decoction combined with Capecitabine+Lenvatinib mesylate in the treatment of PLC patients can effectively improve the objective remission rate of the disease,re-duce the damage of liver function and immune function,delay the progression of the disease,and is safe and reliable.关键词
正肝化症汤/卡培他滨/甲磺酸仑伐替尼/肝功能/T淋巴细胞亚群/肿瘤标志物Key words
Zhenggan Huazheng Decoction/Capecitabine/Lenvatinib mesylate/Liver function/T-lymphocyte subsets/Tu-mor markers分类
医药卫生引用本文复制引用
王利东,王彬彬,段铮,张娟..正肝化症汤加减配合西药治疗对原发性肝癌患者肝功能及T淋巴细胞亚群的影响[J].哈尔滨医药,2024,44(4):112-116,5.基金项目
河南省医学科技攻关联合共建项目(LHGJ20211035) （LHGJ20211035）
