基础医学与临床2024，Vol.44Issue(9)：1208-1213,6.DOI:10.16352/j.issn.1001-6325.2024.09.1208
脑类器官在药物研发中的研究进展
Research progress of brain organoids in drug development
摘要
Abstract
In recent years,with rapid development of technology of regenerative medicine and tissue engineering,brain organoids,as an innovative in vitro model system,have become a hot spot in neuroscience research and drug development.Brain organoids simulate the complex structure and function of the human brain in terms of reprodu-cing key processes of brain development in vitro,providing an unprecedented platform for understanding the mecha-nisms of neurological diseases and of evaluating drug efficacy and toxicity.This review summarizes the latest re-search progress in brain organoid technology,particularly its application in drug development and in exploring chal-lenges and orientation of future development.关键词
脑类器官/疾病模型/药物筛选/精准治疗Key words
brain organoids/disease model/drug screening/precision therapy分类
生物科学引用本文复制引用
王靓,夏隆阔,张建民..脑类器官在药物研发中的研究进展[J].基础医学与临床,2024,44(9):1208-1213,6.基金项目
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-005,2021-I2M-1-035) （2021-I2M-1-005,2021-I2M-1-035）
北京市科技计划项目(Z231100004823031) （Z231100004823031）
