基础医学与临床2024，Vol.44Issue(9)：1214-1218,5.DOI:10.16352/j.issn.1001-6325.2024.09.1214
肿瘤类器官临床前转化研究及应用
Preclinical translational research and application of tumor organoids
摘要
Abstract
More and more in-depth tumor mechanism research and clinical precision treatment have put forward higher requirements for the technology for the establishment of tumor models.More and more tumor organoids have been applied.This model is able to reproduce the genomic,transcriptome,proteome and other omics features of pa-rental tumors without heterogeneity found in cell line models.Based on these characteristics,tumor organoids have gradually become a representative preclinical model,facilitating the translation of new research results and precision treatment of patients.This article summarizes the latest progress of tumor organoids on R&D of technology and appli-cation,focusing on the current methods of establishing tumor organoids,opportunities and challenges in clinical and research application.关键词
肿瘤类器官/精准治疗/类器官生物样本库Key words
tumor organoid/precise treatment/organoid biobank分类
医药卫生引用本文复制引用
夏雨佳,杨振丽,刘玉琴..肿瘤类器官临床前转化研究及应用[J].基础医学与临床,2024,44(9):1214-1218,5.基金项目
中国医学科学院医学与健康科技创新工程-重大协同创新项目(2021-I2M-1-053) （2021-I2M-1-053）
