基础医学与临床2024，Vol.44Issue(9)：1219-1222,4.DOI:10.16352/j.issn.1001-6325.2024.09.1219
胃癌类器官在基础研究与临床应用中的进展
Progress of gastric cancer organoids in basic research and clinical application
摘要
Abstract
Gastric cancer ranks fifth in global cancer mortality,which is highly aggressive and heterogeneous.How-ever,the research and treatment of gastric cancer is hindered by short of research models that may characterize the developmental properties of gastric cancer.Gastric cancer organoid is a multicellular three-dimensional structure de-veloped in vitro,which can mimic the structure and function of native gastric cancer.Gastric cancer organoids have great application potential and development prospects in establishing gastric cancer research models,mimicking the tumor microenvironment,high-throughput screening of drugs,discovering new therapeutic targets,predicting clinical therapeutic responses,and guiding individualized treatment.In this paper,the progress of gastric cancer or-ganoids in basic research and clinical application is reviewed aiming for promoting the progress of preclinical re-search and supporting the clinical treatment of gastric cancer.关键词
胃癌/临床治疗/类器官/肿瘤微环境Key words
gastric cancer/clinical treatment/organoid/tumor microenvironment分类
医药卫生引用本文复制引用
刘保清,黄容,卢艳,李凯,张宁,刘长征,宋伟..胃癌类器官在基础研究与临床应用中的进展[J].基础医学与临床,2024,44(9):1219-1222,4.基金项目
中国医学科学院医学与健康科技创新工程(2021-I2M-1-066) （2021-I2M-1-066）
