吉林中医药2024，Vol.44Issue(8)：987-992,6.DOI:10.13463/j.cnki.jlzyy.2024.08.028
桑源药材的化学成分及治疗2型糖尿病的作用机制研究进展
Research progress of the chemical constituents of mulberry-derived herbs and their mechanisms on treating type 2 diabetes
摘要
Abstract
Mulberry leaves,twigs,white mulberry root-barks,and fruits are derived from Morus alba L.and have good physiological activities.These mulberry-derived herbs contain various chemical components such as flavonoids,alkaloids,polysaccharides,phenolic acids,Diels-Alder-type component,and coumarins,among which flavonoids,polysaccharides,or alkaloids are their characteristic active ingredients.The different parts of mulberry can prevent and treat type 2 diabetes by inhibiting the α-glucosidase activity,protecting pancreatic islets β cells,improving inflammatory reactions and antioxidant stress,regulating the mitochondrial metabolism,regulating intestinal flora,and improving complications of diabetes,etc.In this paper,a systematic review is made on the chemical compositions of the mulberry-derived herbs and their applications and mechanisms in the prevention and treatment of type 2 diabetes,aiming to provide a guidance for their future development and clinical application.关键词
桑叶/桑枝/桑白皮/桑椹/2型糖尿病/作用机制Key words
mulberry leaf/mulberry twig/white mulberry root-bark/mulberry fruit/type 2 diabetes/mechanism分类
医药卫生引用本文复制引用
张艳娇,马凯乐,张宇昕,方心怡,苗润宇,尹瑞阳,关惠芳,田佳星..桑源药材的化学成分及治疗2型糖尿病的作用机制研究进展[J].吉林中医药,2024,44(8):987-992,6.基金项目
国家自然科学基金青年项目(81903891) （81903891）
首都卫生发展科研专项青年优才项目(CD2020-4-4155) （CD2020-4-4155）
中国中医科学院优秀青年科技人才培养专项(ZZ13-YQ-026) （ZZ13-YQ-026）
中国中医科学院科技创新工程项目(CI2021A01601) （CI2021A01601）
转化医学国家重大科技基础设施(上海)开放课题项目(TMSK-2021-407) （上海）
