结直肠癌肝转移患者血清miR-618水平及意义OACSTPCD

Objective To investigate the expression level of miR-618 in patients with colorectal cancer liver metastasis and its clinical significance.Methods A total of 188 patients with colorectal cancer admitted to the hospital from January 2016 to January 2019 were selected as the study objects,which were divided into metas-tasis group(58 cases)and non-metastasis group(130 cases)according to the occurrence of liver metastasis.The preoperative serum miR-618 levels between the two groups and the serum miR-618 levels of liver metas-tasis patients with different clinical characteristics were compared,and the clinical value of serum miR-618 in diagnosing the occurrence of liver metastasis in colorectal cancer patients was analyzed by plotting receiver op-erating characteristic(ROC)curve.The metastasis group was followed up for 3 years and divided into good prognosis group and poor prognosis group according to the prognosis,serum miR-618 levels were compared between the two groups,and ROC curves were plotted to analyze the clinical value of serum miR-618 in pre-dicting the prognosis of patients with liver metastasis.Results Comparison of tumor differentiation degree,infiltration depth and lymph node staging between the metastasis group and the non-metastasis group showed statistically significant differences(P＜0.05).The serum miR-618 level in the metastasis group was 0.70±0.20,which was significantly lower than 1.03±0.40 in the non-metastasis group,and the difference was sta-tistically significant(t=5.803,P＜0.001).The serum miR-618 level in moderately/highly differentiated pa-tients was higher than that in poorly differentiated patients(P＜0.05);the serum miR-618 levels in patients with tumor infiltration depths of stages T3 and T4 were lower than those of stages T1/T2,and serum miR-618 level of stage T4 was lower than that of stage T3,with statistically significant differences(P＜0.05);the serum miR-618 levels of patients with lymph node staging of stages N1 and N2 were lower than those of stage N0,and serum the miR-618 level of stage N2 was lower than that of stage N1,with statistically significant differences(P＜0.05).The result of ROC curve analysis showed that the area under the curve(AUC)of pa-tients with colorectal cancer diagnosed with liver metastasis was 0.883 when the optimal cut-off value of ser-um miR-618 was 0.787.After 3 years follow-up,among 58 patients with liver metastasis,25 cases were in-cluded in the poor prognosis group,and 33 cases in the good prognosis group.The serum miR-618 level in the prognosis group was 0.64±0.20,which was significantly lower than 0.75±0.19 in the good prognosis group(P＜0.05).ROC curve result showed that when the optimal cut-off value of miR-618 was 0.678,the AUC predicting the prognosis of patients with liver metastasis was 0.701.Conclusion The serum miR-618 level in patients with colorectal cancer liver metastases is closely related to the severity of the disease,and the level of miR-618 can assist in the prognosis of patients with liver metastasis.