"半衰期+"室内质控频率新策略在化学发光免疫检测项目中的应用OACSTPCD

Objective To investigate the application of"half-life+"internal quality control frequency in chemiluminescence immunoassay tests by analyzing the characteristics of out-of-control incidents of chemilu-minescence immunoassay testing.Methods A retrospective analysis was performed based on out-of-control data,reasons and measures for internal quality control of chemiluminescence immunoassay tests in Depart-ment of Clinical Laboratory of Chongqing General Hospital from January 2021 to December 2023.The pattern of"half-life+"internal quality control frequency was established and evaluated.Results A total of 326 out-of-control incidents were identified in this study,the quality control product reasons(92.33％),which would not influence the accuracy of sample tests,was the main reason of out-of-control incident;the out-of-control inci-dent by reagent reasons(3.37％),calibrator reasons(2.76％)and other reasons(1.53％)would influence the accuracy of sample tests."Half-life+",a novel strategy,would apparently decrease the frequency of out-of-control incident in internal quality control(0.38％vs.0.16％),and it would influence the accuracy of sample tests.Conclusion In the test of chemiluminescence,the novel"half-life+"strategy of internal quality control can make sure a reliable tests system,while it also can decrease the frequency of internal quality control and"false out-of-control incident",saving cost of manpower and material resources and improving management of laboratory quality.